PREPARATION AND PHYSICOCHEMICAL PROPERTIES OF SUPRAMOLECULAR COMPLEXES OF ECDYSTERONE
Meteleva E.S. Eduardovich P.N. Iglikovich T.B. Serikovich T.B. Valerievich D.A. Mynzhasarovich A.S.
2023Altai State University
Khimiya Rastitelnogo Syrya
2023Issue 4209 - 217 pp.
The supramolecular complexes of ecdysterone (20E), an active ingredient of many adaptogenic and anabolic drugs, with 2-hydroxypropyl-β-cyclodextrin (2-HP-β-CD) and disodium salt of glycyrrhizic acid (Na2GA) were prepared by mechanochemical method throw the formation of solid dispersion (SD) of components. These complexes have been studied, both in solutions and solid state by various physicochemical methods, 1H NMR spectroscopy, HPLC, differential scanning calorimetry and X-ray diffraction analysis in comparison with the initial ecdysterone. It was found that the water solubility of 20E at 37°C was increased by 3.0 and 2.7 times for 20E/2-HP-β-CD and 20E/Na2GA complexes, respectively. Also, the transmembrane permeability of E20 and its supramolecular complexes through artificial membranes has been evaluated by PAMPA assay. The results indicate the prospects of using 20E/2-HP-β-CD and 20E/Na2GA complexes for increasing absorption in the gastrointestinal tract. In addition, the advantages of green mechanochemical technology of inclusion complexes preparation have been demonstrated.
Cyclodextrins , Ecdysterone , Glycyrrhizic acid , Mechanochemistry , NMR spectroscopy , Permeability , Pharmaceutics Solid Dispersions , Solubility
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Institute of Solid State Chemistry and Mechanochemistry, SB RAS, Kutateladze st. 18, Novosibirsk, 630128, Russian Federation
Institute of Chemical Kinetics and Combustion, SB RAS, Institutskaya st. 3, Novosibirsk, 630090, Russian Federation
International Research and Production «Holding Phytochemistry», Gazalieva st. 4, Karaganda, 100009, Kazakhstan
Institute of Solid State Chemistry and Mechanochemistry
Institute of Chemical Kinetics and Combustion
International Research and Production «Holding Phytochemistry»
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