Application of Half-Sandwich Metal-Phosphinite Compounds to Biological Activities: Determine the energies of the HOMO and LUMO levels
Meriç N. Rafikova K. Zazybin A. Güzel R. Kayan C. Elma Karakaş D. Dündar A. Islam S. Okumuş V. Aydemir M.
17 January 2023John Wiley and Sons Inc
Zeitschrift fur Anorganische und Allgemeine Chemie
2023#649Issue 2
Mononuclear transition metal complexes 1-(furan-2-yl)ethyldiphenyl[dichloro(η6-p-cymene)ruthenium(II)]phosphinite, (2), 1-(furan-2-yl)ethyldiphenyl[dichloro(η6-benzene) ruthenium(II)] phosphinite (3), 1-(furan-2-yl)ethyldipheny[chloro(η4-1,5-cyclooctadiene)rhodium(I)]phosphinite (4), 1-(furan-2-yl)ethyldiphenyl[dichloro (η5pentamethylcyclopentadienyl)iridium (III)] phosphinite (5) were synthesized and characterized by microanalysis, infrared, MS, and NMR spectroscopy. The biological activities of the complexes were also tested. Compounds 2 and 5 were the best complexes at DPPH radical scavenging and reducing power activity at 73.27 % and 0.41 at 200 μg/mL, respectively. The highest antimicrobial activity exhibited by complex 3 as 14 mm inhibition zone against S. aureus. All of the complexes have cleaved the DNA from the double-strand and exhibited three bands on gel electrophoresis. Moreover, cyclic voltammetry studies of the phosphinite complexes were carried out to determine the energies of the HOMO and LUMO levels as well as to estimate their electrochemical and some electronic properties.
Biological Study , Electron transport , Phosphinite Ligand , Transition metal
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Department of Chemistry, Faculty of Science, Dicle University, Diyarbakir, 21280, Turkey
Institute of Geology and Oil and Gas Engineering, Satbayev University, Almaty, Kazakhstan
School of Chemical Engineering, Kazakh-British Technical University, Almaty, Kazakhstan
Department of Science, Faculty of Education, Dicle University, Diyarbakir, 21280, Turkey
Science and Technology Application and Research Center (SIUBTAM), Siirt University, Siirt, 56100, Turkey
Vocational High School of Health Services, Mardin Artuklu University, Mardin, 47100, Turkey
Department of Medical Biology, Faculty of Medicine, Siirt University, Siirt, 56100, Turkey
Department of Chemistry
Institute of Geology and Oil and Gas Engineering
School of Chemical Engineering
Department of Science
Science and Technology Application and Research Center (SIUBTAM)
Vocational High School of Health Services
Department of Medical Biology
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