Biomarkers of oxidative stress in pregnant women in the third trimester: Predictors of severe chronic arterial hypertension (original research)

Meiramova T.K. Murzasheva G.K. Omertaeva D.E. Mugazov M.M. Alpysova A.R. Matayeva L.M.
2025 Kaz Med Print LLP

Reproductive Medicine (Central Asia)
2025 #2025 Issue 2 133 - 143 pp.

Relevance: Severe chronic arterial hypertension (HTN) in pregnant women increases the risk of maternal and fetal complications, partly due to oxidative stress caused by an imbalance between the production of reactive oxygen species (ROS) and antioxidant defense. The study aimed to compare the levels of oxidative stress biomarkers—advanced oxidation protein products (AOPP), membranebound protein (MBP), oxidatively modified erythrocyte proteins (OMBe), oxidatively modified plasma proteins (OMBp), methylglyoxal in erythrocytes (MGe) and plasma (MGp), beta-2-microglobulin (B2M)—in pregnant women with severe chronic hypertension and healthy pregnant women in the third trimester, investigate correlations between these biomarkers and clinical parameters, and identify predictors of hypertension using logistic regression. Materials and Methods: A retrospective cross-sectional study included 68 pregnant women in the third trimester: 40 with severe HTN (Group 1) and 28 healthy controls (Group 2). Comparative analysis (Mann-Whitney U-test), correlation analysis (Spearman’s coefficient), and binary logistic regression were performed. Results: Group 1 exhibited elevated levels of AOPP (p < 0.001), OME (p < 0.001), and B2M (p < 0.001) but reduced OMP (p = 0.003). AOPP and B2M showed a strong correlation (ρ = 0.48, p < 0.001) and were independent predictors of HTN (OR = 2.4 for AOPP, 95% CI: 1.5–3.9; OR = 1.9 for B2M, 95% CI: 1.2–3.1). Conclusion: AOPP and B2M are promising biomarkers for monitoring severe HTN in pregnancy, reflecting oxidative and renal stress. Their use may facilitate risk stratification and the development of targeted interventions.

AOPP , B2M , oxidative stress , pregnancy , severe arterial hypertension

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Department of Obstetrics, Gynecology, and Perinatology, Karaganda Medical University, Karaganda, Kazakhstan
Department of Emergency Medicine, Anesthesiology, and Intensive Care, Karaganda Medical University, Karaganda, Kazakhstan
Department of Emergency Medical Care, Anesthesiology and Resuscitation, Karaganda Medical University, Karaganda, Kazakhstan

Department of Obstetrics
Department of Emergency Medicine
Department of Emergency Medical Care

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