Biophysical perspectives of the spatiotemporal dynamics of plasma coagulation under flow
Megalinskii A.D. Nechipurenko Y.D. Panteleev M.A. Nechipurenko D.Y.
October 2025Springer Science and Business Media Deutschland GmbH
Biophysical Reviews
2025#17Issue 51529 - 1541 pp.
Gelation of blood plasma is key to normal hemostasis. The regulation of coagulation in blood flow has been studied for several decades, but the key problems in the field remain unresolved. Understanding the major mechanisms governing coagulation under flow conditions is important for the development of new diagnostic tools, therapeutic agents, and novel strategies addressing pathological states associated with both hypo- and hypercoagulation. In this review, we highlight the general features of plasma coagulation under flow conditions, including its spatiotemporal dynamics and threshold dependence on the key parameters. A short overview of in vitro and in silico models and important breakthroughs that became possible with their combination is followed by a brief introduction into the analysis of the balance between convection, diffusion, and reactions using Peclet and Damköhler numbers. We highlight the major unresolved challenges in the field and share an overall perspective of the future directions that might help to clarify the important questions that emerged during the last decade of intensive research.
Blood clotting , Blood flow , Computation modeling , Hemostasis , Microfluidics , Plasma coagulation
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Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences, Moscow, 109029, Russian Federation
Department of Physics, School of Sciences and Humanities, Nazarbayev University, Astana, 010000, Kazakhstan
Laboratory of DNA-Protein Interactions, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991, Russian Federation
Faculty of Physics, Lomonosov Moscow State University, Moscow, 119234, Russian Federation
Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, 117198, Russian Federation
Center for Theoretical Problems of Physicochemical Pharmacology
Department of Physics
Laboratory of DNA-Protein Interactions
Faculty of Physics
Dmitry Rogachev National Research Center of Pediatric Hematology
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