Multimorbidity in osteoarthritis and pleiotropic effects of slow-acting symptomatic drugs. Resolution of the multidisciplinary International Expert Council
Mazurov V.I. Lila A.M. Alekseeva L.I. Baymukhamedov C.T. Isaeva B.G. Iskra D.A. Karimov M.Y. Mirakhmedova H.T. Mkrtumyan A.M. Nabieva D.A. Naumov A.V. Tkacheva O.N. Trofimov E.A. Khokhlova M.N.
2023Ima-Press Publishing House
Sovremennaya Revmatologiya
2023#17Issue 5123 - 131 pp.
In recent decades, the prevalence of osteoarthritis (OA), one of the most disabling diseases, has increased worldwide, which imposes a significant burden on society. At the international multidisciplinary meeting, experts of various specialties (rheumatology, neurology, endocrinology, geriatrics, rehabilitation, traumatology and orthopedics) from Russia, Uzbekistan, and Kazakhstan discussed the importance of an individualized approach to the treatment of patients with OA, taking into account comorbidities, identified the most important and common clinical phenotypes of the disease, discussed known symptom- and structure-modifying effects of a combination of glucosamine and chondroitin sulfate, and new data on additional (pleiotropic) effects of these drugs that may have a positive impact on the course of comorbid diseases and conditions. The resolution of the Expert Council summarizes the results of the discussion and focuses on issues that are important for the further development of therapeutic approaches and recommendations for the management of such patients.
chondroitin sulfate , glucosamine , multimorbidity , osteoarthritis , phenotype , pleiotropic effects , Theraflex
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North-Western State Medical University named after I.I. Mechnikov, Ministry of Health of Russia, 41, Kirochnaya Street, St. Petersburg, 191015, Russian Federation
V.A. Nasonova Research Institute of Rheumatology, 34A, Kashirskoe Shosse, Moscow, 115522, Russian Federation
Department of Rheumatology Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia, 2/1, Barrikadnaya Street, Build. 1, Moscow, 125993, Russian Federation
Center of Joint Diseases, 32A, Sasbukaeva Street, Shymkent, 160013, Kazakhstan
Asfendiyarov Kazakh National Medical University, 94, Tole Bi Street, Almaty, 050012,, Kazakhstan
Military Medical Academy named after S.M. Kirov, Ministry of Defense of Russia, 66, Academik Lebedev Street, St. Petersburg, 194044, Russian Federation
Tashkent Medical Academy, 2, Farabi Street, Tashkent, 100109, Uzbekistan
Moscow State Medical Dentistry University, 4, Dolgorukovskaya Street, Moscow, 127006, Russian Federation
Russian Gerontological Research Clinical Center, Pirogov Russian National Research Medical University, Ministry of Health of Russia, 16, 1st Leonova Street, Moscow, 129226, Russian Federation
Moscow Centre foe Research and Practice in Medical Rehabilitation, Restorative and Sports Medicine, Moscow Healthcare Department, 53, Zemlyanoy Val Street, Moscow, 105120, Russian Federation
North-Western State Medical University named after I.I. Mechnikov
V.A. Nasonova Research Institute of Rheumatology
Department of Rheumatology Russian Medical Academy of Continuing Professional Education
Center of Joint Diseases
Asfendiyarov Kazakh National Medical University
Military Medical Academy named after S.M. Kirov
Tashkent Medical Academy
Moscow State Medical Dentistry University
Russian Gerontological Research Clinical Center
Moscow Centre foe Research and Practice in Medical Rehabilitation
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