Highly efficient CT contrast agent based on barium-doped mesoporous silica nanoparticles (SiO2-Ba NPs)
Mazhit A. Zhumanova K. Duisenbayeva B. Atabaev T.S.
15 December 2023Elsevier B.V.
Materials Letters
2023#353
The synthesis of nanoparticles-based contrast agents (CA) has gained momentum in recent years due to their superior contrasting properties over conventional molecular counterparts. Herein, for the first time, we present the synthesis and contrasting properties evaluation of small (<50 nm) barium-doped mesoporous silica nanoparticles (SiO2-Ba NPs). We found that the X-ray attenuation efficiency of SiO2-Ba NPs was ∼4.5 times higher than that of a medically-employed Iopromide contrast agent under the same conditions. A leaching test revealed that the maximum level of Ba2+ ions escape was negligible indicating that the prepared SiO2-Ba NPs are structurally stable. Overall, the prepared SiO2-Ba NPs show great promise as effective CT contrast agents.
Biomaterials , Nanoparticles , Porous materials , Powder technology
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Department of Chemistry, Nazarbayev University, Astana, Kazakhstan
Department of Radiology, Republican Diagnostic Center, Astana, Kazakhstan
Department of Chemistry
Department of Radiology
10 лет помогаем публиковать статьи Международный издатель
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