Maternal-fetal cytomegalovirus infection : experience in Liege and new antenatal screening and care strategy

Infection materno-fœtale à cytomégalovirus. Expérience liégeoise et nouvelle stratégie de dépistage et de prise en charge anténatale

Summmary : In Belgium, as in most developed countries, routine antenatal screening for cytomegalovirus (CMV) remains controversial and is not recommended. However, 1-2 % of seronegative pregnant women will develop a primary infection during pregnancy and, with a prevalence of 0.7 % of live births, CMV is the leading cause of congenital infection. Among infected newborns, 20 to 25 % will develop auditory or neurological sequelae. The initial objective of our study was to evaluate, from a cohort of 48 patients followed in the antenatal diagnosis Unit of the University Hospital of Liège, the rates of maternal-fetal transmission, medical termination of pregnancy and rates of sequelae in infected newborns and to compare them with findings found in the literature. The second objective was to synthesize the current state of knowledge on maternal-fetal CMV infection and, in the light of recent data on prenatal treatment with valaciclovir, to propose a screening and management algorithm for primary CMV infection in the first trimester of pregnancy.

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Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026