Towards experimental models of delirium utilizing zebrafish
Maslov G.O. Zabegalov K.N. Demin K.A. Kolesnikova T.O. Kositsyn Y.M. de Abreu M.S. Petersen E.V. Kalueff A.V.
13 September 2023Elsevier B.V.
Behavioural Brain Research
2023#453
Delirium is an acute neuropsychiatric condition characterized by impaired behavior and cognition. Although the syndrome has been known for millennia, its CNS mechanisms and risk factors remain poorly understood. Experimental animal models, especially rodent-based, are commonly used to probe various pathogenetic aspects of delirium. Complementing rodents, the zebrafish (Danio rerio) emerges as a promising novel model organism to study delirium. Zebrafish demonstrate high genetic and physiological homology to mammals, easy maintenance, robust behaviors in various sensitive behavioral tests, and the potential to screen for pharmacological agents relevant to delirium. Here, we critically discuss recent developments in the field, and emphasize the developing utility of zebrafish models for translational studies of delirium and deliriant drugs. Overall, the zebrafish represents a valuable and promising aquatic model species whose use may help understand delirium etiology, as well as develop novel therapies for this severely debilitating disorder.
Delirium , Drug screening , Experimental models , Zebrafish
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Neurobiology Program, Sirius University of Science and Technology, Sochi, Russian Federation
National Laboratory Astana, Nazarbayev University, Astana, Kazakhstan
Institute of Experimental Medicine, Almazov National Medical Research Centre, Ministry of Healthcare of Russian Federation, St. Petersburg, Russian Federation
Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russian Federation
Novosibirsk State University, Novosibirsk, Russian Federation
Laboratory of Preclinical Bioscreening, Granov Russian Research Center of Radiology and Surgical Technologies, Ministry of Healthcare of Russian Federation, Pesochny, Russian Federation
Ural Federal University, Ekaterinburg, Russian Federation
Laboratory of Cell and Molecular Biology and Neurobiology, Moscow Institute of Physics and Technology, Moscow, Russian Federation
Neurobiology Program
National Laboratory Astana
Institute of Experimental Medicine
Institute of Translational Biomedicine
Novosibirsk State University
Laboratory of Preclinical Bioscreening
Ural Federal University
Laboratory of Cell and Molecular Biology and Neurobiology
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