Rationale for processing of a mg-zn-ca alloy by equal-channel angular pressing for use in biodegradable implants for osteoreconstruction
Martynenko N.S. Anisimova N.Yu. Rybalchenko O.V. Kiselevskiy M.V. Rybalchenko G. Straumal B. Temralieva D. Mansharipova A.T. Kabiyeva A.O. Gabdullin M.T. Dobatkin S. Estrin Y.
November 2021MDPI
Crystals
2021#11Issue 11
Widespread use of Mg-Zn-Ca alloys in clinical orthopedic practice requires improvement of their mechanical properties—in particular, ductility—and enhancement of their bioactivity for accelerated osteoreconstruction. The alloy was studied in two structural states: after homogenization and after equal-channel angular pressing. Immersion and potentiodynamic polarization tests showed that the corrosion rate of the alloy was not increased by deformation. The mass loss in vivo was also statistically insignificant. Furthermore, it was found that deformation did not compromise the biocompatibility of the alloy and did not have any significant effect on cell adhesion and proliferation. However, an extract of the alloy promoted the alkaline phosphatase activity of human mesenchymal stromal cells, which indicates osteogenic stimulation of cells. The osteoinduction of the deformed alloy significantly exceeded that of the homogenized one. Based on the results of this work, it can be concluded that the alloy Mg-1%Zn-0.3%Ca modified by equal-channel angular pressing is a promising candidate for the manufacture of biodegradable orthopedic implants since it stimulates osteogenic differentiation and has greater ductility, which provides it with a competitive advantage in comparison with the homogenized state.
Alkaline phosphatase activity , Biocompatibility , Biodegradation , Equal-channel angular pressing , Magnesium alloy , Osteoconduction
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A.A. Baikov Institute of Metallurgy and Materials Science of the RAS, Moscow, 119334, Russian Federation
N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation (N.N. Blokhin NMRCO), Moscow, 115478, Russian Federation
College of NewMaterials and Nanotechnologies, National University of Science and Technology “MISIS”, Moscow, 119071, Russian Federation
P.N. Lebedev Physical Institute of the RAS, Moscow, 142432, Russian Federation
Institute of Nanotechnology, Karlsruhe Institute of Technology, Hermann-von-Helmholtz-Platz 1, Eggenstein-Leopoldshafen, 76344, Germany
Osipyan Institute of Solid State Physics and Chernogolovka Scientific Center of the Russian Academy of Sciences, Chernogolovka, 142432, Russian Federation
Faculty of General Medicine, College of NewMaterials and Nanotechnologies, Kazakh-Russian Medical University, Almaty, 050000, Kazakhstan
Association of Early Career Doctors of Almaty, Almaty, 050000, Kazakhstan
Institute of Engineering and Information Technologies, Kazakh British Technical University, Almaty, 050000, Kazakhstan
Department of Materials Science and Engineering, Monash University, Clayton, 3800, Australia
Department of Mechanical Engineering, The University of Western Australia, Nedlands, 6009, Australia
A.A. Baikov Institute of Metallurgy and Materials Science of the RAS
N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation (N.N. Blokhin NMRCO)
College of NewMaterials and Nanotechnologies
P.N. Lebedev Physical Institute of the RAS
Institute of Nanotechnology
Osipyan Institute of Solid State Physics and Chernogolovka Scientific Center of the Russian Academy of Sciences
Faculty of General Medicine
Association of Early Career Doctors of Almaty
Institute of Engineering and Information Technologies
Department of Materials Science and Engineering
Department of Mechanical Engineering
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