Particulate reinforced bone cements: The potential antibacteric role of nitrides
Marin E. Boschetto F. Honma T. Yang Q. Ajunwa O.M. Marsili E. Zhu W. Pezzotti G.
May 2023Elsevier B.V.
Materialia
2023#28
In recent years, silicon nitride (Si3N4) ceramics have gained popularity as bioactive structural materials with the capability to stimulate cell proliferation and fight pathogens. Despite displaying bioactive properties and having an excellent mechanical strength, the number of possible applications for silicon nitride is somehow limited by its brittle nature and high production costs. In this work, particles of Si3N4 have been added to Poly(methyl metachylate) (PMMA) bone cements to verify how this reinforcement influences mechanical and antibacterial properties. 5, 10 and 15% weight fractions of powders with average mesh size 25, 50 and 300 μm were mixed together with PMMA and molded into testing samples. Results of the in vitro testing with Escherichia coli and Staphylococcus epidermidis showed that the antibacterial effects of Si3N4 correlate positively with the fraction of ceramic used and are negatively correlated with the mesh size of the powders. Moreover, the smaller particles at the lowest concentration acted as a mechanical reinforcement, increasing the ultimate tensile strength of the composite by about 10%.
Antibacterial , Composites , Dental resins , Mechanical properties , Particulate , PMMA , Silicon nitride
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Ceramic Physics Laboratory, Kyoto Institute of Technology, Sakyo-ku, Kyoto, Matsugasaki, 606-8585, Japan
Department of Dental Medicine Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Kamigyo-ku, 602-8566, Japan
Dipartimento Politecnico di Ingegneria e Architettura, University of Udine, Udine, 33100, Italy
Center for Excellence in Hip, Scottish Rite for Children, Dallas, TX, United States
Biofilm Laboratory Department of Chemical and Materials Engineering, School of Engineering and Digital Sciences, Nazarbayev University, 53 Kabanbay Batyr Avenue, Astana, 01000, Kazakhstan
Nottingham Ningbo China Beacons of Excellence Research and Innovation Institute, Xingguang Road 211, Ningbo, China
Department of Immunology Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Kamigyo-ku, 602-8566, Japan
The Center for Advanced Medical Engineering and Informatics, Osaka University, Yamadaoka, Osaka, Suita, 565-0871, Japan
Ceramic Physics Laboratory
Department of Dental Medicine Graduate School of Medical Science
Dipartimento Politecnico di Ingegneria e Architettura
Center for Excellence in Hip
Biofilm Laboratory Department of Chemical and Materials Engineering
Nottingham Ningbo China Beacons of Excellence Research and Innovation Institute
Department of Immunology Graduate School of Medical Science
The Center for Advanced Medical Engineering and Informatics
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