Culture conversion at six months in patients receiving bedaquiline- and delamanid-containing regimens for the treatment of multidrug-resistant tuberculosis
Maretbayeva S.M. Rakisheva A.S. Adenov M.M. Yeraliyeva L.T. Algozhin Y.Z. Stambekova A.T. Berikova E.A. Yedilbayev A. Rich M.L. Seung K.J. Issayeva A.M.
December 2021Elsevier B.V.
International Journal of Infectious Diseases
2021#113S91 - S95 pp.
Rifampicin-resistant/multidrug-resistant (RR/MDR) and extensively drug-resistant (XDR) strains of M. tuberculosis (TB) are serious public health problem in Kazakhstan. In 2012 and 2013, stringent regulatory authorities approved the first new TB drugs in fifty years, bedaquiline and delamanid, offering hope for more effective and less toxic MDR-TB treatment. The endTB Observational Study is a multi-country study that enrolled patients receiving a bedaquiline- or delamanid-containing regimen for RR/MDR-TB between 01 April 2015 and 30 September 2018. In Kazakhstan, 675 patients participated in the study; all had at least 6-months or longer of follow-up after the start of treatment. The present analysis focuses on endTB Observational Study patients living in Kazakhstan who had a positive baseline sputum culture (220 patients) and initiated a bedaquiline- or delamanid-containing regimen between February 1, 2016 and March 31, 2018. Of them, 195 (89%) of patients experienced culture conversion within six months.
antitubercular agents , extensively drug-resistant tuberculosis , multidrug-resistant , tuberculosis
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Partners In Health, Almaty, Kazakhstan
JSC “National Medical University” named after Asfendiyarov, Kazakhstan
National Scientific Center of Phthisiopulmonology of the Ministry of Health of the Republic of Kazakhstan, Kazakhstan
World Health Organization Regional Office for Europe, Kazakhstan
Partners In Health, Boston, United States
Harvard Medical School, Boston, United States
Partners In Health
JSC “National Medical University” named after Asfendiyarov
National Scientific Center of Phthisiopulmonology of the Ministry of Health of the Republic of Kazakhstan
World Health Organization Regional Office for Europe
Partners In Health
Harvard Medical School
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