HiFormer: a fast and accurate deep learning model for segmentation and detection of glaucoma


Mamyrbayev O. Zhanegizov A. Momynzhanova K. Keylan A.
January 2026Springer

Journal of Supercomputing
2026#82Issue 1

Glaucoma is a leading cause of irreversible blindness, and early detection is critical for preventing vision loss. This paper presents HiFormer, a hybrid deep learning model that combines convolutional neural networks (CNNs) with a hierarchical attention-based transformer architecture to improve the segmentation and classification of fundus images. Unlike traditional CNN-based methods, HiFormer leverages hierarchical attention to better capture multi-scale features and subtle pathological changes associated with glaucoma. The model is trained and evaluated on both open-source datasets and clinical data from the Scientific Research Institute of Eye Diseases in Kazakhstan. Experimental results demonstrate that HiFormer outperforms standard CNN architectures, achieving a 2.91% increase in Dice coefficient and a 16.99 unit decrease in average Hausdorff Distance (HD) compared to TransUnet, and a 1.26% increase in Dice coefficient and 6.85 unit decrease in average HD compared to Swin-Unet. These metrics indicate enhanced accuracy, sensitivity, and computational efficiency, making it well-suited for real-time clinical applications. This work contributes to developing faster and more reliable diagnostic tools for glaucoma detection using retinal imaging.

Computational efficiency , Glaucoma detection , Hybrid neural networks

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Laboratory of Computer Engineering of Intelligent Systems, Institute of Information and Computational Technologies, 28 Shevchenko, Almaty, 050010, Kazakhstan
Faculty of Mechanics and Mathematics, L.N. Gumilyov Eurasian National University, 2 Satbaev, Astana, 10000, Kazakhstan

Laboratory of Computer Engineering of Intelligent Systems
Faculty of Mechanics and Mathematics

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