The effectiveness of micronized progesterone in the complex therapy of ‘thin endometry’ syndrome

Mamedalieva N.M. Kurmanova A.M. Baikoshkarova S.B. Issenova S. Bishekova B. Anartayeva G.Z.
2021 Taylor and Francis Ltd.

Gynecological Endocrinology
2021 #37 Issue S1 26 - 30 pp.

The article presents the results of examination of 30 patients with a history of miscarriage and ‘thin’ endometrium in comparison with 20 patients without reproductive loss and the presence of normal endometrial thickness. The dynamics of intracellular production of γ-INF, IL-1 and IL-10 by cytotoxic endometrial lymphocytes was studied by flow cytometry. It was found that before treatment in patients with miscarriage and thin endometrium syndrome there was a significant (12-fold) decrease in the level of CD8+ cytotoxic/suppressor lymphocytes (p <.01), a 2.8-fold decrease in the level of CD56+ cells, and also a sharp inhibition of the level of intracellular production of cytokines - γ-INF (8 times), IL-1 (11 times) and IL-10 (15 times). Against the background of complex therapy, including the elimination of pathogenic pathogens, antiplatelet therapy, intrauterine ultrasound cavitation and personalized hormonal therapy using intravaginal micronized progesterone (Luteina), an increase of endometrial thickness was observed: M-echo from 5.9 ± 0.1 to 10.2 ± 0.2 mm; the frequency of visualization of uterine vessels increased to 80–100%; in the spiral arteries, the pulsation index significantly decreased—PI (1.43 ± 0.04 vs. 0.79 ± 0.06), resistance index RI (0.96 ± 0.05 vs. 0.54 ± 0.04), systolic–diastolic ratio S/D in the uterine (4.5 ± 0.04 vs. 2.3 ± 0.05) and arcuate arteries (3.67 ± 0.04 vs. 2.41 ± 0.02); and there was also a positive dynamics of intracellular cytokine production with a significant (p <.05) increase in the level of IL-1 and IL-10, as well as the level of γ-IFN CD56+ by endometrial lymphocytes.

cytotoxic endometrial lymphocytes , IL-1 , IL-10 , interferon , micronized progesterone , Miscarriage , thin endometrial syndrome

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Scientific Center for Obstetrics, Gynecology and Perinatology, Almaty, Kazakhstan
Obstetrics and Gynecology Department, S.D. Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
Clinical specialties Department, Al-Farabi Kazakh National University, Almaty, Kazakhstan
IVF Clinic Ecomed, Almaty, Kazakhstan

Scientific Center for Obstetrics
Obstetrics and Gynecology Department
Clinical specialties Department
IVF Clinic Ecomed

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