Effects of a combination of resveratrol and alpha-lipoic acid on body weight and adipose composition in women with PCOS: a preliminary pilot study
Malvasi A. Tinelli A. Lupica G. Vimercati A. Spyropoulou K. Dellino M. Mynbaev O.
2022Verduci Editore s.r.l
European Review for Medical and Pharmacological Sciences
2022#26Issue 186578 - 6582 pp.
OBJECTIVE: Polycystic ovary syndrome is associated with reproductive and metabolic dysfunction; in fact, treatment aims in PCOS focus on optimizing healthy weight, improving underlying hormonal disturbances, preventing future reproductive and metabolic complications, and improving quality of life. PATIENTS AND METHODS: This pilot study considered 8 overweight females (BMI > 30) in reproductive age with PCOS. Patients were treated with a galenical preparation mixture containing resveratrol and alpha-lipoic acid in association with vitamin D, B and folic acid for 12 weeks, after which anthropometric assessment was conducted. RESULTS: After 12 weeks of treatment, BMI, anthropometry and bioimpedance parameters were all reduced in the treated patients compared to baseline. CONCLUSIONS: The present nutraceutical combination resulted beneficial for improving the metabolic profile of women with PCOS, paving the way for new nutraceutical strategies for the management of metabolic disturbances in PCOS.
Alpha-lipoic acid , Metabolic syndrome , PCOS , Resveratrol
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Laboratory of Human Physiology, Phystech BioMed School, Faculty of Biological & Medical Physics, Moscow Institute of Physics and Technology (State University), Moscow Region, Dolgoprudny, Russian Federation
Department of Biomedical Sciences and Human Oncology, Gynecologic and Obstetrics Clinic, University of Bari Aldo Moro, Bari, Italy
Department of Obstetrics and Gynecology, Veris Delli Ponti Hospital, Scorrano, Lecce, Italy
Department of Obstetrics and Gynecology, Ioannina State General Hospital G. Chatzikosta, Ioannina, Greece
Department of Obstetrics and Gynecology, San Paolo Hospital, Bari, Italy
Khoja Akhmet Yassawi International Kazakh-Turkish University, Turkestan, Kazakhstan
The Principal Researcher, MIPT-National Research University, Moscow, Russian Federation
Laboratory of Human Physiology
Department of Biomedical Sciences and Human Oncology
Department of Obstetrics and Gynecology
Department of Obstetrics and Gynecology
Department of Obstetrics and Gynecology
Khoja Akhmet Yassawi International Kazakh-Turkish University
The Principal Researcher
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