Frontiers of Ferroptosis in Cancer Treatment
Malik D.-E.-S. Romero M.A. Halim S.F.M. Elsori D. Youssef L. Yulaevna I.M. Sabitaliyevich U.Y. Attar R.
2022Cellular and Molecular Biology Association
Cellular and Molecular Biology
2022#68Issue 214 - 19 pp.
Recent phenomenal advancements in genomic and proteomic technologies and rapid breakthroughs in the interpretation of large gene expression datasets have enabled scientists to comprehensively characterize the gene signatures involved in ferroptosis. Ferroptosis is an iron-dependent form of non-apoptotic cell death that has gained the worthwhile attention of both basic and clinical researchers. Ferroptosis has dichotomous, context-dependent functions both as a tumor suppressor and promoter of carcinogenesis. Essentially, pharmacological modulation of ferroptosis by its induction as well as its inhibition holds enormous potential to overcome drug resistance and to improve the therapeutic potential of chemotherapeutic drugs in a wide variety of cancers. Copyright:
Apoptosis , Cancer , Cell signaling , Ferroptosis
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Institute of Pharmaceutical Sciences, PUMHSW, Nawabshah, Pakistan
Facultad de Medicina, Universidad Autónoma de Guerrero, Laboratorio de Investigación Clínica, Av. Solidaridad S/N, Colonia Hornos Insurgentes, cp 39300, Guerrero, Acapulco, Mexico
Rashid Latif Medical College, Lahore, Pakistan
Faculty of Resilience, Rabdan Academy, Abu Dhabi, United Arab Emirates
Department of Biomedical Sciences, Faculty of Medicine and Medical Sciences, University of Balamand (UOB), Al-Kurah, Lebanon
E. A. Buketov Karaganda University, Kazakhstan
Scientific Center for Innovative Technologies and Research, Kazakhstan
Department of Obstetrics and Gynecology, Yeditepe University, Turkey
Institute of Pharmaceutical Sciences
Facultad de Medicina
Rashid Latif Medical College
Faculty of Resilience
Department of Biomedical Sciences
E. A. Buketov Karaganda University
Scientific Center for Innovative Technologies and Research
Department of Obstetrics and Gynecology
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