Candidate protein biomarkers in chronic kidney disease: a proteomics study
Makhammajanov Z. Kabayeva A. Auganova D. Tarlykov P. Bukasov R. Turebekov D. Kanbay M. Molnar M.Z. Kovesdy C.P. Abidi S.H. Gaipov A.
December 2024Nature Research
Scientific Reports
2024#14Issue 1
Proteinuria poses a substantial risk for the progression of chronic kidney disease (CKD) and its related complications. Kidneys excrete hundreds of individual proteins, some with a potential impact on CKD progression or as a marker of the disease. However, the available data on specific urinary proteins and their relationship with CKD severity remain limited. Therefore, we aimed to investigate the urinary proteome and its association with kidney function in CKD patients and healthy controls. The proteomic analysis of urine samples showed CKD stage-specific differences in the number of detected proteins and the exponentially modified protein abundance index for total protein (p = 0.007). Notably, specific urinary proteins such as B2MG, FETUA, VTDB, and AMBP exhibited robust negative associations with kidney function in CKD patients compared to controls. Also, A1AG2, CD44, CD59, CERU, KNG1, LV39, OSTP, RNAS1, SH3L3, and UROM proteins showed positive associations with kidney function in the entire cohort, while LV39, A1BG, and CERU consistently displayed positive associations in patients compared to controls. This study suggests that specific urinary proteins, which were found to be negatively or positively associated with the kidney function of CKD patients, can serve as markers of dysfunctional or functional kidneys, respectively.
Biomarkers , Chronic kidney disease , Proteinuria , Urinary proteomics
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Department of Biomedical Sciences, School of Medicine, Nazarbayev University, Astana, Kazakhstan
Department of Internal Medicine, Astana Medical University, Astana, Kazakhstan
Department of Proteomics and Mass Spectroscopy, National Center for Biotechnology, Astana, Kazakhstan
Department of Chemistry, School of Sciences and Humanities, Nazarbayev University, Astana, Kazakhstan
Division of Nephrology, Department of Internal Medicine, Koc University, Istanbul, Turkey
Division of Nephrology & amp; Hypertension, Department of Internal Medicine, Spencer Fox Eccles School of Medicine at the University of Utah, Salt Lake City, UT, United States
Division of Nephrology, Department of Medicine, University of Tennessee Health Science Center, Memphis, TN, United States
Department of Medicine, School of Medicine, Nazarbayev University, Astana, Kazakhstan
Clinical Academic Department of Internal Medicine, University Medical Center, Astana, Kazakhstan
Department of Biomedical Sciences
Department of Internal Medicine
Department of Proteomics and Mass Spectroscopy
Department of Chemistry
Division of Nephrology
Division of Nephrology & amp; Hypertension
Division of Nephrology
Department of Medicine
Clinical Academic Department of Internal Medicine
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