The impact of endometrial microbiota on in vitro fertilization outcomes: A literature review
Makhadiyeva D.B. Baikoshkarova S.B. Ibragimov A.K. Azhetova Z.R. Мynbayeva М.Z. Теrzic М.
2 October 2024Kaz Med Print LLP
Reproductive Medicine (Central Asia)
2024#2024Issue 316 - 22 pp.
Relevance: Despite significant advancements in assisted reproductive technologies (ART), the failure rate of infertility treatments remains relatively high, highlighting the need for further investigation into factors affecting the success of in vitro fertilization (IVF) procedures. Current research in reproductive medicine increasingly recognizes the endometrial microbiotas critical role in infertility treatment success. The study aimed to summarize the data on the relationship between endometrial microbiota and infertility treatment outcomes using IVF. Materials and Methods: We conducted a literature review by analyzing published research studies in English and Russian, focusing on the impact of endometrial microbiota on IVF outcomes. The literature search was carried out in databases such as PubMed, Scopus, Web of Science, and Google Scholar, covering the period from 2014 to 2024. Results: Existing data indicate complex relationships between specific microbiota profiles and reproductive health, with particular emphasis on Lactobacillus species, considered potential markers of a healthy endometrial environment. However, the lack of standardized microbiota characterization and variability in sampling methods underscore the challenges in establishing definitive associations. Furthermore, the analysis shows that current studies often suffer from tiny sample sizes, limiting the generalizability of the findings. Conclusion: This review highlights the need for larger-scale prospective studies with stringent methodological standards to understand better the role of endometrial microbiota in predicting IVF outcomes. A deeper understanding of the role of microbiota in implantation promises to revolutionize preventive, diagnostic, and therapeutic strategies in reproductive medicine, paving the way for personalized treatment approaches.
assisted reproductive technologies (ART) , endometrium , in vitro fertilization (IVF) , infertility , microbiota
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Ecomed Plus, Аstana, Kazakhstan
Nazarbayev University, Аstana, Kazakhstan
Ecomed Medical Group, Аstana, Kazakhstan
Astana Medical University, Аstana, Kazakhstan
Ecomed Plus
Nazarbayev University
Ecomed Medical Group
Astana Medical University
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