Association of Working Status with Clinical Pregnancy and Miscarriage among Women undergoing In Vitro Fertilization: Single-Centre Cross-Sectional Study
Makhadiyeva D. Ibragimov A. Baikoshkarova S. Terzic M.M. Issanov A.
July 2024Royan Institute (ACECR)
International Journal of Fertility and Sterility
2024#18Issue 3215 - 221 pp.
Background: Middle-aged working women represent most patients attending fertility clinics for in vitro fertilization (IVF) treatment. In this study, we aimed to identify the association of women’s working status with clinical pregnancy and miscarriage in the first trimester after IVF treatment. Materials and Methods: In this single-centre cross-sectional study at a private clinic in Kazakhstan, we reviewed electronic medical records of all IVF with intracytoplasmic sperm injection (ICSI) and fresh embryo transfer (ET) cycles from January 2018 to December 2019 (n=654). 300 cycles in patients with normal ovarian reserve and registered working status of a female partner in the medical records were selected for the analysis. The studys primary outcome measures were clinical pregnancy rates and clinical miscarriage in the first trimester. Results: 204 women were employed, while 96 were not employed before the start of treatment. The mean age of all patients was 32.2 ± 4.8 years, ranging from 23 to 46 years. Two-thirds of working women had office-based occupations employed as doctors, school and university teachers, accountants, clerks, and managers. One-third of the study participants had manual labor jobs, including service positions and plant workers. There was no association between women’s working status and clinical pregnancy rate adjusted for age, antral follicle count, history of pelvic adhesiolysis, and embryo development stage at embryo transfer. However, working women had almost five times the risk of the first trimester miscarriage compared to non-working women [adjusted odds ratio (aOR) 4.56, 95% confidence interval (CI): 0.52 to 4.96] adjusted for age and number of retrieved oocytes. Conclusion: Women who work before commencing IVF treatment can be reassured of having equal chances of conception following the treatment compared to non-working women. The observed risk of first trimester miscarriage in working women necessitates further research before drawing any conclusions from medical and public health points.
Assisted Reproductive Techniques , In Vitro Fertilization , Intracytoplasmic Sperm Injection
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Department of Medicine, School of Medicine, Nazarbayev University, Astana, Kazakhstan
Ecomed Fertility Clinic, Astana, Kazakhstan
Department of Surgery, School of Medicine, Nazarbayev University, Astana, Kazakhstan
Clinical Academic Department of Women’s Health, National Research Center of Mother and Child Health, University Medical Center, Astana, Kazakhstan
Department of Obstetrics, Gynecology and Reproductive Sciences, School of Medicine, University of Pittsburgh, Pittsburgh, United States
Department of Medicine
Ecomed Fertility Clinic
Department of Surgery
Clinical Academic Department of Women’s Health
Department of Obstetrics
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