Herbal remedies in the management of hyperuricemia and gout: A review of in vitro, in vivo and clinical evidences
Mahomoodally M.F. Coodian K. Hosenally M. Zengin G. Shariati M.A. Abdalla A.N. Alhazmi H.A. Khuwaja G. Mohan S. Khalid A.
July 2024John Wiley and Sons Ltd
Phytotherapy Research
2024#38Issue 73370 - 3400 pp.
Gout, or hyperuricemia is a multifactorial and multi-faceted metabolic disease that is quite difficult to manage and/or treat. Conventional therapies such as non-steroidal anti-inflammatory drugs (NSAIDs) such as allopurinol, corticosteroids and colchicine amongst others, have helped in its management and treatment to some extent. This study aimed to compile and analyze the different herbal remedies used in the management of hyperuricemia and gout. A literature search was conducted from key databases (PubMed, ScienceDirect, Cochrane Library, Google Scholar) using relevant keywords via the PRISMA model. Smilax riparia A.DC. from Traditional Chinese Medicine is used in many countries for its therapeutic effect on lowering serum urate levels. No single study was able to establish the efficacy of a specific traditionally used herb via in vitro, in vivo, and clinical studies. Patients were found to use a panoply of natural remedies, mainly plants to treat hyperuricemia and gout, which have been validated to some extent by in vitro, in vivo, and clinical studies. Nonetheless, further research is needed to better understand the ethnopharmacological relationship of such herbal remedies.
dietary supplements , gout , herbal medicine , hyperuricemia
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Institute of Research and Development, Duy Tan University, Da Nang, Viet Nam
School of Engineering & Technology, Duy Tan University, Da Nang, Viet Nam
Department of Health Sciences, Faculty of Medicine and Health Sciences, University of Mauritius, Réduit, Mauritius
Department of Economics and Statistics, Faculty of Social Sciences & Humanities, University of Mauritius, Réduit, Mauritius
Department of Biology, Faculty of Science, Selcuk University, Konya, Turkey
Semey Branch of the Institute, Kazakh Research Institute of Processing and Food Industry, Almaty, Kazakhstan
Department of Pharmacology and Toxicology, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia
Substance Abuse and Toxicology Research Center, Jazan University, Jazan, Saudi Arabia
Department of Pharmaceutical Chemistry and Pharmacognosy, College of Pharmacy, Jazan University, Jazan, Saudi Arabia
School of Health Sciences, University of Petroleum and Energy Studies, Dehradun, India
Medicinal and Aromatic Plants and Traditional Medicine Research Institute, National Center for Research, Khartoum, Sudan
Institute of Research and Development
School of Engineering & Technology
Department of Health Sciences
Department of Economics and Statistics
Department of Biology
Semey Branch of the Institute
Department of Pharmacology and Toxicology
Substance Abuse and Toxicology Research Center
Department of Pharmaceutical Chemistry and Pharmacognosy
School of Health Sciences
Medicinal and Aromatic Plants and Traditional Medicine Research Institute
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