Nutritional Sources and Anticancer Potential of Phenethyl Isothiocyanate: Molecular Mechanisms and Therapeutic Insights
M. Ezzat S. M. Merghany R. M. Abdel Baki P. Ali Abdelrahim N. M. Osman S. A. Salem M. Peña-Corona S.I. Cortés H. Kiyekbayeva L. Leyva-Gómez G. Sharifi-Rad J. Calina D.
April 2024John Wiley and Sons Inc
Molecular Nutrition and Food Research
2024#68Issue 8
Phenethyl isothiocyanate (PEITC), a compound derived from cruciferous vegetables, has garnered attention for its anticancer properties. This review synthesizes existing research on PEITC, focusing on its mechanisms of action in combatting cancer. PEITC has been found to be effective against various cancer types, such as breast, prostate, lung, colon, and pancreatic cancers. Its anticancer activities are mediated through several mechanisms, including the induction of apoptosis (programmed cell death), inhibition of cell proliferation, suppression of angiogenesis (formation of new blood vessels that feed tumors), and reduction of metastasis (spread of cancer cells to new areas). PEITC targets crucial cellular signaling pathways involved in cancer progression, notably the Nuclear Factor kappa-light-chain-enhancer of activated B cells (NF-κB), Protein Kinase B (Akt), and Mitogen-Activated Protein Kinase (MAPK) pathways. These findings suggest PEITCs potential as a therapeutic agent against cancer. However, further research is necessary to determine the optimal dosage, understand its bioavailability, and assess potential side effects. This will be crucial for developing PEITC-based treatments that are both effective and safe for clinical use in cancer therapy.
anticancer properties , apoptosis , cancer management , molecular mechanisms , phenethyl isothiocyanate , signaling pathways
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Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Kasr El-Ainy Street, Cairo, 11562, Egypt
Department of Pharmacognosy, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), Giza, 12451, Egypt
Pharmacognosy Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre (NRC), 33 El-Bohouth Street, Dokki, Giza, Egypt
Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), Giza, 12451, Egypt
Department of Pharmacognosy and Natural Products, Faculty of Pharmacy, Menoufia University, Gamal Abd El Nasr St., Menoufia, Shibin El Kom, 32511, Egypt
Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, 04510, Mexico
Laboratorio de Medicina Genómica, Departamento de Genómica, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Ciudad de México, Mexico
Department of Pharmaceutical Technology, Pharmaceutical School, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
Facultad de Medicina, Universidad del Azuay, Cuenca, Ecuador
Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, Craiova, 200349, Romania
Pharmacognosy Department
Department of Pharmacognosy
Pharmacognosy Department
Faculty of Pharmacy
Department of Pharmacognosy and Natural Products
Departamento de Farmacia
Laboratorio de Medicina Genómica
Department of Pharmaceutical Technology
Facultad de Medicina
Department of Clinical Pharmacy
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