Mixed-valence hexanuclear CoII,III complex with amidoxime: synthesis, structure, and in vitro biological activity against the non-pathogenic strain of Mycolicibacterium smegmatis


Lutsenko I.A. Vologzhanina A.V. Kayukova L.A. Yergalieva E.M. Koshenskova K.A. Bekker O.B. Dorovatovskii P.V. Eremenko I.L.
October 2022Springer

Russian Chemical Bulletin
2022#71Issue 102172 - 2178 pp.

The reaction of cobalt(ɪɪ) chloride with p-Br-benzoyl-β-(piperidin-1-yl)propioamid-oxime (Linit) in methanol leads to the hydrolysis of the ligand at the -OCO- ester bond and the formation of the mixed-valence hexanuclear ionic complex [CoII2CoIII4(HL)4(L)2(O)-(Cl)4]Cl2•4CH3OH (1) (L is β-(piperidin-l-yl)propioamidoxime). According to the X-ray diffraction data, the ligand (L) in 1 is coordinated to the complexing agent in different modes: the μ3-bridging-chelating mode (involving deprotonated amino groups) and the μ2- and μ3-bridging-chelating modes in the case of a coordinated amino group. Two cobalt atoms of the hexanuclear metal core have a tetrahedral coordination geometry (CoIIN2Cl2; CNCoII = 4), whereas the other four cobalt atoms are in an octahedral coordination environment of nitrogen and oxygen atoms forming the polyhedra of composition CoIIIO3N3 and CoIIIO4N2 (CNCoIII = 6). The evaluation of the in vitro biological activity of 1 against the non-pathogenic (virulent H37Rv model) mycobacterial strain of Mycolicibacterium smegmatis showed an increase in the efficiency of complex 1 by more than 4–12 times compared to the previously studied CoII,III complexes.

amidoxime , biological activity , cobalt , coordination compounds , non-pathogenic strain of Mycolicibacterium smegmatis , structure

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N. S. Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, 31 Leninsky prosp., Moscow, 119991, Russian Federation
A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28 ul. Vavilova, Moscow, 119991, Russian Federation
A. B. Bekturov Institute of Chemical Sciences, 106 Shokan Ualikhanov str., Almaty, 050010, Kazakhstan
N. I. Vavilov Institute of General Genetics, Russian Academy of Sciences, 3 ul. Gubkina, Moscow, 119334, Russian Federation
National Research Center “Kurchatov Institute”, 1 ul. Akad. Kurchatova, Moscow, 123182, Russian Federation

N. S. Kurnakov Institute of General and Inorganic Chemistry
A. N. Nesmeyanov Institute of Organoelement Compounds
A. B. Bekturov Institute of Chemical Sciences
N. I. Vavilov Institute of General Genetics
National Research Center “Kurchatov Institute”

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