Finding a molecular genetic marker for the incidence of recurrent episodes of acute obstructive bronchitis in children
Lukianenko N. Kens O. Nurgaliyeva Z. Toguzbayeva D. Sakhipov M.
1 January 2021Carol Davila University Press
Journal of Medicine and Life
2021#2021Issue 5695 - 699 pp.
Over the last ten years, the incidence of the pathology of the bronchus-pul-monary system in children has increased 3.6 times, mainly due to acute and recurrent inflammatory diseases of the upper and lower respiratory tract. Thus, the problem of identifying children with recurrent episodes of acute obstructive bronchitis and an increased risk of developing asthma is relevant and promising. The goal of this study was to find molecular genetic markers associated with increased susceptibility of children to repeated episodes of acute obstructive bronchitis. The molecular genetic testing of the IL4 gene of a single nucleotide polymorphism C-33T was performed in 35 children with recurrent episodes of acute obstructive bronchitis and 35 children with acute bronchitis. The results were statistically processed on a personal computer with the calculation of values the arithmetic mean (M), of the errors arithmetic mean (m), Student criterion (t), the degree of probability (p), Pearson criterion (χ²), and the odds ratio (OR). Statistically significant differences were figured at p<0.01 and p<0.05. It has been proved that the presence of a child’s genotype 33СT IL4 increases the risk of recurrent acute obstructive bronchitis four times.
IL4 gene , single nucleotide polymorphism C-33T , Student criterion , testing
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Department of Clinical Genetics, Institute of Hereditary Pathology of the National Academy of Medical Sciences of Ukraine, Lviv, Ukraine
Department of Propaedeutics of Pediatrics and Medical Genetics, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine
Department of Pharmacology, West Kazakhstan Marat Ospanov State Medical University, Aktobe, Kazakhstan
Department of Otorhinolaryngology, Kazakh Medical University of Continuing Education, Almaty, Kazakhstan
Department of Surgery with a Course of Anesthesiology and Resuscitation, Kazakh-Russian Medical University, Almaty, Kazakhstan
Department of Clinical Genetics
Department of Propaedeutics of Pediatrics and Medical Genetics
Department of Pharmacology
Department of Otorhinolaryngology
Department of Surgery with a Course of Anesthesiology and Resuscitation
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