Current Trends in Treatment for Acid-Dependent Diseases: Clinical Efficacy and Safety of Rabeprazole
Актуальные тенденции в лечении кислотозависимых заболеваний: клиническая эффективность и безопасность рабепразола
Lopina O.D. Nurgalieva B.K. Lapina T.L.
2021Gastro LLC
Russian Journal of Gastroenterology, Hepatology, Coloproctology
2021#31Issue 455 - 63 pp.
Aim. A comparative review of the rabeprazole properties vs. other PPIs, its efficacy and safety in treatment for acid-dependent diseases. Key points. Rabeprazole provides a rapid proton pump blockade in parietal cells due to its high dissociation constant (pKa). A lower rabeprazole metabolic dependence on cytochrome P-450 enzyme system renders its antisecretory effect predictable and reduces the risk of interactions with other drugs metabolised through this system. A faster antisecretory effect and higher acid-suppressive activity of rabeprazole determine its better clinical efficacy in treatment for such acid-dependent diseases as gastroesophageal reflux disease and peptic ulcer. This makes rabeprazole (Pariet) a preferred drug in course and maintenance therapies for acid-dependent diseases, as well as in H. pylori eradication. Conclusion. The rabeprazole properties of high acid suppression potential, persistent antisecretory effect from first day of therapy, non-enzymatic metabolism and pleiotropic action determine its high efficacy in treatment for a wide range of acid-dependent diseases at a minimal risk of drug interaction.
Gastroesophageal reflux disease , H. pylori eradication therapy , Peptic ulcer , Proton pump inhibitor deprescribing , Proton pump inhibitors , Rabeprazole , Safety
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Biology Faculty, M.V. Lomonosov Moscow State University, Leninskie gory, 1, bld. 12, Moscow, 119234, Russian Federation
Asfendiyarov Kazakh National Medical University, Tole bi str., 94, Almaty, 050062, Kazakhstan
KhAK Medical Centre LLP, Tole bi str., 94, Almaty, 050062, Kazakhstan
I.M. Sechenov First Moscow State Medical University (Sechenov University), Pogodinskaya str., 1, bld. 1, Moscow, 119435, Russian Federation
Biology Faculty
Asfendiyarov Kazakh National Medical University
KhAK Medical Centre LLP
I.M. Sechenov First Moscow State Medical University (Sechenov University)
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