Is spermatozoa epigenome a diagnostic tool for assessing male infertility?
Lokshin V.N. Nigmetova K.T. Begimbaeva A.A. Sailau Z.K. Ashirbekov E.E. Ermekova A.Sh. Meiri-Ferber B. Karibaeva S.K. Sharipov K.O. Cassuto N.G. Wolf J.Ph.
2024Kaz Med Print LLP
Reproductive Medicine (Central Asia)
2024#2024Issue 39 - 15 pp.
Relevance: The sperm epigenome is essential in ensuring sperm quality, including maintaining chromatin integrity. However, despite its importance, a clear link between successful embryo development and clinical outcomes has not been established. The study aimed to assess the influence of sperm epigenetics on the quality and development of the embryo and identify the molecular mechanisms involved in this process. Materials and Methods: A search in the PubMed database and the World Health Organization documents for 2012-2023 was conducted using the following keywords: assisted reproductive technologies, in vitro fertilization, male infertility, sperm, spermatozoa, epigenome, and intracytoplasmic sperm injection. Results: The analysis of current publications revealed that the relationship between the sperm epigenome and embryo development remains the subject of active research. The degree of influence of the sperm epigenome on the fertilization process, early embryo development, and the outcome of the IVF program continues to cause debate. Conclusion: The study of epigenetic changes in spermatozoa of men who have infertility opens new horizons for understanding the mechanisms affecting fertility and embryo quality. Understanding the epigenetic processes affecting spermatogenesis and embryogenesis may contribute to improving the results of ART and may also offer new approaches to the treatment of male infertility. Future research in this area may provide new insights into the mechanisms underlying male infertility.
assisted reproductive technologies (ART) , epigenome , in vitro fertilization (IVF) , intracytoplasmic sperm injection (ICSI) , male infertility , sperm , spermatozoa
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National Academy of Sciences of the Republic of Kazakhstan, International Clinical Center for Reproductology “Persona,”, Almaty, Kazakhstan
Laboratory of Structural and Functional Genomics, Institute of Molecular Biology and Biochemistry named after M.A. Aitkhozhina, Almaty, Kazakhstan
Embryology Laboratory, International Clinical Center of Reproductology “PERSONA”, Kazakh National University named after. Al-Farabi, Almaty, Kazakhstan
Laboratory Drouot Unit AMP, Paris, France
Department of Andrology, Andrologia MD-Cytobit, Tel Aviv, Israel
Université Paris Cité, Paris, France
Department of Reproductive Biology CECOS, AP-HP, Center-Université Paris Cite, Cochin Hospital, Paris, France
Department of Obstetrics and Gynecology, S.D. Asfendiyarov Kazakh National Medical University, Director for Strategic Development, International Clinical Center of Reproductology “PERSONA”, Almaty, Kazakhstan
National Academy of Sciences of the Republic of Kazakhstan
Laboratory of Structural and Functional Genomics
Embryology Laboratory
Laboratory Drouot Unit AMP
Department of Andrology
Université Paris Cité
Department of Reproductive Biology CECOS
Department of Obstetrics and Gynecology
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