EXPERIENCE WITH BOVHYALURONIDASE AZOXIMER USED IN THE COMBINATION TREATMENT OF CHRONIC ENDOMETRITIS IN WOMEN WITH REPEATED IMPLANTATION FAILURES

Lokshin V.N. Askar Y. Rybina A.N. Abshekenova A.T. Karibayeva S.K. Valiev R.K.
2023 Bionika Media Ltd.

Akusherstvo i Ginekologiya (Russian Federation)
2023 #2023 Issue 5 108 - 112 pp.

Objective: To evaluate the efficiency of using bovhyaluronidase azoximer in the combination treatment of chronic endometritis in women with repeated implantation failures (RIFs). Materials and methods: Examinations were made in 84 women with chronic endometritis and RIFs who had been treated using in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) in the “PERSONA” International Clinical Center of Reproductology (Almaty, Kazakhstan) in January 2020 to January 2022 and followed up within 9 months after treatment. Two groups were identified by the treatment method: a study group that received antibacterial therapy in combination with bivhyaluronidase azoximer; a control group used antibacterial therapy alone. Results: After treatment, a negative result to the expression of CD138⁺ cells was considerably frequent in the study group than in the control group (0.88±1.27 versus 6.48±7.40; p=0.00014). The pregnancy rate in the first cycle after transfer of a single frozen-thawed embryo was statistically higher in the study group than in the control group (78% versus 41.1%; р<0.001). Accordingly, the live birth rate was also higher in the study group than in the control group (62% versus 32.3%; р=0.008). Conclusion: Chronic endometritis frequently occurs in women with RIFs. The results of the conducted study showed the high efficiency of using bovhyaluronidase azoximer in combination with antibacterial therapy, a substantial reduction in the expression of CD138⁺ cells, and increases in the rate of pregnancy, and the live birth rates in this category of women.

bovhyaluronidase azoximer , CD138⁺ , chronic endometritis , outcomes of IVF/ICSI , RIF

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“PERSONA” International Clinical Center of Reproductology, Utepova 32a, Almaty, Kazakhstan
Asfendiyarov Kazakh National Medical University, Utepova 32a, Almaty, Kazakhstan

“PERSONA” International Clinical Center of Reproductology
Asfendiyarov Kazakh National Medical University

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