Transition metal-free selective C-S bond cleavage of Ugi-adducts for rapid preparation of peptidomimetics
Liu C. Song L. Peshkov V.A. Van der Eycken E.V.
11 March 2022Royal Society of Chemistry
Green Chemistry
2022#24Issue 72783 - 2787 pp.
A transition metal-free C-S bond cleavage and subsequent Mannich reaction of Ugi-adducts with alcohols as well as thiols is developed. Diverse novel peptidomimetics containing N,O- or N,S-aminals are synthesized in a rapid, highly efficient and step-economical fashion. This method features exclusive selectivity, broad substrate scope, excellent yield and functional group tolerance, and was applied on substrates derived from the pharmaceuticals febuxostat, probenecid and memantine.
Text of the article Перейти на текст статьи
Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), KU Leuven Celestijnenlaan 200F, Department of Chemistry, Leuven, 3001, Belgium
Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-Forest Biomass, Nanjing Forestry University, College of Chemical Engineering, International Innovation Center for Forest Chemicals and Materials, Jiangsu Key Lab of Biomass-Based Green Fuels and Chemicals, Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Jiangsu, Nanjing, 210037, China
College of Chemistry, Soochow University, Chemical Engineering and Materials Science, Dushu Lake Campus, Suzhou, 215123, China
Department of Chemistry, Nazarbayev University, School of Sciences and Humanities, 53 Kabanbay Batyr Ave, Nur-Sultan, 010000, Kazakhstan
Peoples’ Friendship University of Russia (RUDN University), Miklukho-Maklaya Street 6, Moscow, 117198, Russian Federation
Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC)
Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-Forest Biomass
College of Chemistry
Department of Chemistry
Peoples’ Friendship University of Russia (RUDN University)
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026