The synthesis of diverse benzazepinoindoles via gold-catalyzed post-Ugi alkyne hydroarylation/Michael addition sequence
Liu C. Van Meervelt L. Peshkov V.A. Van der Eycken E.V.
14 July 2022Royal Society of Chemistry
Organic Chemistry Frontiers
2022#9Issue 174619 - 4624 pp.
We have developed a novel gold-catalyzed hydroarylation/Michael addition process, enabling the construction of the benzazepinoindole polycyclic scaffold in a highly efficient manner starting from readily accessible multifunctional Ugi adducts. The developed methodology is characterized by a broad substrate scope, excellent functional-group tolerance and high yields of the target benzazepinoindoles.
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Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, KU Leuven, Celestijnenlaan 200F, Leuven, 3001, Belgium
Biomolecular Architecture, Department of Chemistry, KU Leuven, Celestijnenlaan 200F, Leuven, 3001, Belgium
College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Dushu Lake Campus, Suzhou, 215123, China
Department of Chemistry, School of Sciences and Humanities, Nazarbayev University, 53 Kabanbay Batyr Ave, Nur-Sultan, 010000, Kazakhstan
Peoples’ Friendship University of Russia (RUDN University), Miklukho-Maklaya Street 6, Moscow, 117198, Russian Federation
Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC)
Biomolecular Architecture
College of Chemistry
Department of Chemistry
Peoples’ Friendship University of Russia (RUDN University)
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