Palladium-catalyzed post-Ugi arylative dearomatization/Michael addition cascade towards plicamine analogues
Liu C. Zhao R. Song L. Li Z. Tian G. He Y. Van Meervelt L. Peshkov V.A. Van der Eycken E.V.
28 November 2021Royal Society of Chemistry
Organic and Biomolecular Chemistry
2021#19Issue 449752 - 9757 pp.
A palladium-catalyzed intramolecular cyclization of Ugi-adductsviaa cascade dearomatization/aza-Michael addition process has been developed. Diverse plicamine analogues are constructed in a rapid, highly efficient and step-economical manner, through the combination of an Ugi-4CR and a palladium-catalyzed dearomatization. The synthetic utility of this approach is illustrated by further functional group transformations.
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Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, KU Leuven Celestijnenlaan 200F, Leuven, 3001, Belgium
Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-Forest Biomass, Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Jiangsu Key Lab of Biomass-Based Green Fuels and Chemicals, International Innovation Center for Forest Chemicals and Materials, College of Chemical Engineering, Nanjing Forestry University, Jiangsu, Nanjing, 210037, China
Biomolecular Architecture, Department of Chemistry, KU Leuven Celestijnenlaan 200F, Leuven, 3001, Belgium
College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Dushu Lake Campus, Suzhou, 215123, China
Department of Chemistry, School of Sciences and Humanities, Nazarbayev University, 53 Kabanbay Batyr Ave, Nur-Sultan, 010000, Kazakhstan
Peoples’ Friendship University of Russia (RUDN University), Miklukho-Maklaya Street 6, Moscow, 117198, Russian Federation
Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC)
Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-Forest Biomass
Biomolecular Architecture
College of Chemistry
Department of Chemistry
Peoples’ Friendship University of Russia (RUDN University)
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