Facile construction of peptidomimetics by sequential C-S/C-N bond activation of Ugi-adducts
Liu C. Song L. Peshkov V.A. Van Der Eycken E.V.
21 December 2021Royal Society of Chemistry
Organic Chemistry Frontiers
2021#8Issue 246968 - 6973 pp.
A novel selectively sequential C-S/C-N bond activation is presented. Through the combination of an Ugi-4CR and sequential C-S/C-N bond cleavage, diverse peptidomimetics containing a primary amide are prepared in a rapid, highly efficient and step-economical manner. This approach exhibits high yield, excellent chemoselectivity and functional group tolerance. Compounds derived from the pharmaceuticals febuxostat, probenecid and memantine as well as β-amino acid are prepared. This method provides a new direction for the synthesis of peptidomimetics. This journal is
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Laboratory for Organic and Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, KU Leuven, Celestijnenlaan 200F, Leuven, 3001, Belgium
Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-Forest Biomass, Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Jiangsu Key Lab of Biomass-Based Green Fuels and Chemicals, International Innovation Center for Forest Chemicals and Materials, College of Chemical Engineering, Nanjing Forestry University, Jiangsu, Nanjing, 210037, China
College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Dushu Lake Campus, Suzhou, 215123, China
Department of Chemistry, School of Sciences and Humanities, Nazarbayev University, 53 Kabanbay Batyr Ave, Nur-Sultan, 010000, Kazakhstan
Peoples Friendship University of Russia, RUDN University, Miklukho-Maklaya Street 6, Moscow, 117198, Russian Federation
Laboratory for Organic and Microwave-Assisted Chemistry (LOMAC)
Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-Forest Biomass
College of Chemistry
Department of Chemistry
Peoples Friendship University of Russia
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