Concentration Indicator Kit Based on Dandelion Propagation-Inspired SERS Strategy
Li G. Yi L. Zhang S. Song Q. Liang M. Guan Z. Zhang Y. Zhuang Y. Hou B. Wang X. Wu X. Yin P. Dmitriy K. Yang J. Hu B. Tian J.
28 August 2025John Wiley and Sons Inc
Advanced Materials
2025#37Issue 34
Surface-enhanced Raman scattering (SERS) technology has been extensively employed for the detection of liquid samples in the biomedical field due to high sensitivity and non-invasive characteristics. However, quantitative SERS detection is hindered by sophisticated instrumentation and complex calibration procedures, while qualitative analyses often provide insufficient concentration information for clinical diagnosis. Herein, a concentration indicator kit based on dandelion propagation-inspired SERS strategy is developed for the semi-quantitative detection of drug residues in urine. This strategy achieves significant signal enhancement through the synergistic effects of optimized hotspot construction and molecular adsorption, resulting in an analytical enhancement factor of 2.503 × 10⁵, which is 4143 times greater than that of silver nanoparticles. An innovative phenomenon termed the “concentration indicator” is discovered, wherein the SERS signal is dramatically enhanced at specific indicated concentrations while remaining weak at adjacent concentrations. The practical utility of this kit is validated through the detection of 2-mercaptobenzothiazole in urine samples. The kit exhibits excellent performance in semi-quantitative detection of standard solutions and simulated samples at high, indicated, and low concentrations. The concentration indicator opens new avenues for the development of simplified and reliable SERS-based detection, offering a promising platform for bedside testing in medical diagnostics.
concentration indicator , hotspot construction , molecular adsorption , semi-quantitative detection , SERS strategy
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School of Life Science and Technology, Xidian University, Shaanxi, Xian, 710126, China
School of Mathematics and Physics Science and Engineering, Hebei University of Engineering, Hebei, Handan, 056038, China
Institute of Life Sciences, Karaganda Medical University, Karaganda, 100008, Kazakhstan
State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China
Xian Intelligent Precision Diagnosis and Treatment International Science and Technology Cooperation Base, Shaanxi, Xian, 710126, China
Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China
School of Life Science and Technology
School of Mathematics and Physics Science and Engineering
Institute of Life Sciences
State Key Laboratory of Oncology in South China
Xian Intelligent Precision Diagnosis and Treatment International Science and Technology Cooperation Base
Institute of Automation
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