Salvia dumetorum essential oil: GC-MS analysis, antibacterial activity and effect on the formation of Streptococcus mutans biofilms
Levaya Y. Atazhanova G. Kacergius Т. Ivasenko S. Marchenko A.B. Ishmuratova M.Y. Smagulov М.
2024Taylor and Francis Ltd.
Natural Product Research
2024#38Issue 203555 - 3561 pp.
Salvia dumetorum essential oil (SDEO) was obtained using a Clevenger apparatus by hydrodistillation approach. The chemical composition of the essential oil was determined by GC-MS analysis. In this study SDEO was screened for its antibacterial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Candida albicans and the amount of biofilm formed by Streptococcus mutans bacteria. For the first time the chemical composition of SDEO growing in Central Kazakhstan was established. The results obtained from GC-MS showed the predominance of sesquiterpenoids (54.15%). The antibacterial study results showed that SDEO exhibited strong antibacterial activity against B. subtilis and S. aureus in vitro and also demonstrated an inhibitory effect on S. mutans biofilm formation on 1% sucrose medium. During the study, no antibacterial activity was detected against E. coli and C. albicans. These results demonstrated that SDEO can be used in the development of new antibacterial and anti-caries therapeutic dental products.
antibacterial activity , Essential oil , GC-MS , isolation , Salvia dumetorum , Salvia stepposa , sesquiterpenes
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School of Pharmacy, NJSC ‘Karaganda Medical University’, Karaganda, Kazakhstan
Department of Physiology, Biochemistry, Microbiology and Laboratory Medicine, Institute of Biomedical Sciences, Faculty of Medicine, Vilnius University, Lithuania
Department of Botany, NJSC ‘E.A. Buketov Karaganda University’, Karaganda, Kazakhstan
School of Pharmacy
Department of Physiology
Department of Botany
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