Validity and Reliability of the French Olfactory Disorders Questionnaire-10

Lechien J.R. Vaira L.A. Lamoulen L. Sowerby L. Radulesco T. Michel J. Boscolo-Rizzo P. Salzano G. Barillari M.R. Saibene A.M. Cammaroto G. Chiesa-Estomba C.M. Iannella G. Van der Poel N. Sagandykova K. Saussez S. Carsuzaa F. Mayo-Yanez M. Bhargava E.K. Maniaci A. Briganti G.
1 January 2025

Journal of otolaryngology - head & neck surgery = Le Journal doto-rhino-laryngologie et de chirurgie cervico-faciale
2025 #54 19160216251387622 pp.

ImportanceMost French Olfactory Questionnaires are time consuming, which may affect the patient participation.ObjectiveTo validate a short French version of the Olfactory Disorders Questionnaire (Fr-ODQ).DesignProspective controlled study.SettingMulticenter study.ParticipantsPatients with long-lasting olfactory dysfunction (OD) treated with platelet-rich plasma into the olfactory clefts and asymptomatic subjects.InterventionDevelopment and validation of a short ODQ.Main OutcomesIndividuals completed the full Fr-ODQ. The Threshold, Discrimination, and Identification (TDI) test was performed in OD patients. A combined statistical analysis was performed to determine the most informative items of the Fr-ODQ to develop a shorter version. The internal consistency was determined with Cronbachs alpha. The reliability and external validity were evaluated through a test-retest approach and by correlating with the Fr-ODQ. Both the minimal clinically important difference (MCID) and the threshold of the short ODQ version were determined.ResultsA total of 263 patients (173 [65.8%] females) and 129 controls (92 [71.3%] females) completed the evaluations. The mean age of patients was 51.2 ± 15.3 years. The mean duration of OD was 42.4 ± 54.3 months. The biostatistical models selected 10 essential items composing the Fr-ODQ-10. The baseline Fr-ODQ-10 was significantly correlated with the TDI (rs = 0.228; P = .001) and the Fr-ODQ (rs = 0.875; P = .001), demonstrating high external validity. Fr-ODQ-10 was significantly lower in controls compared to OD patients (P = .001), highlighting high internal validity. The internal consistency was good (α = .796). The external consistency was adequate, with significant correlations between the test-retest Fr-ODQ-10. The Fr-ODQ-10 significantly decreased from baseline to 4 months post-treatment. A Fr-ODQ-10 score >7.5 was considered abnormal (sensitivity: 84.8%, specificity: 84.2%). The MCID of Fr-ODQ-10 was established at >3.Conclusion and RelevanceThe Fr-ODQ-10 is a valid and reliable clinical instrument, demonstrating correlation with the psychophysical olfactory assessment.

anosmia , odor , olfaction , Olfactory Disorder Questionnaire , otolaryngology , rhinology , smell

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Department of Surgery, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons, Mons, Belgium
Department of Otolaryngology, Elsan Hospital, Paris, France
Department of Otorhinolaryngology-Head & Neck Surgery, Foch Hospital, School of Medicine, UFR Simone Veil, Université Versailles Saint-Quentin-en-Yvelines (Paris Saclay University), Paris, France
Department of Otolaryngology-Head & Neck Surgery, CHU Saint-Pierre, Brussels, Belgium
Olfaction Group of the Young Otolaryngologists of the International Federation of Otorhinolaryngological Societies (IFOS), Paris, France
Maxillofacial Surgery Operative Unit, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy
Biomedical Science Department, PhD School of Biomedical Science, University of Sassari, Sassari, Italy
Department of Computational Medicine and Neuropsychiatry, University of Mons, Mons, Belgium
Department of Otolaryngology-Head & Neck Surgery, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada
Aix Marseille Univ, APHM, CNRS, IUSTI, La Conception University Hospital, Department, Marseille, France
Section of Otolaryngology, Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy
Maxillofacial Surgery Unit, Department of Neurosciences, Reproductive and Odontostomatological Sciences, University Federico II, Naples, Italy
Division of Phoniatrics and Audiology, Department of Mental and Physical Health and Preventive Medicine, University of Naples SUN, Naples, Italy
Otolaryngology Unit, ASST Santi Paolo E Carlo, Department of Health Sciences, Università Degli Studi Di Milano, Milan, Italy
Department of Otolaryngology-Head & Neck Surgery, Forli Hospital, Forli, Italy
Department of Otorhinolaryngology-Head & Neck Surgery, Hospital Universitario Donostia, San Sebastian, Spain
Department of Organi di Senso, Sapienza Università di Roma, Rome, Italy
Department of Otorhinolaryngology-Head & Neck Surgery, Antwerp University Hospital, Edegem, Belgium
Department of Translational Neuroscience, Faculty of Medicine and Health Science, University of Antwerp, Antwerp, Belgium
University Medical Center Corporate Fund, School of Medicine, Nazarbayev University, Astana, Kazakhstan
Department of Human Anatomy and Experimental Oncology, University of Mons, Mons, Belgium
Department of Otolaryngology-Head & Neck Surgery, CHU de Poitiers, Poitiers, France
Department of Otorhinolaryngology-Head & Neck Surgery, Complexo Hospitalario Universitario A Coruña (CHUAC), A Coruña, Spain
Department of ENT, Sheffield Childrens Hospital, Sheffield, United Kingdom
Faculty of Health, University of Sheffield, Sheffield, United Kingdom
Department of Medicine and Surgery, University of Enna Kore, Enna, Italy

Department of Surgery
Department of Otolaryngology
Department of Otorhinolaryngology-Head & Neck Surgery
Department of Otolaryngology-Head & Neck Surgery
Olfaction Group of the Young Otolaryngologists of the International Federation of Otorhinolaryngological Societies (IFOS)
Maxillofacial Surgery Operative Unit
Biomedical Science Department
Department of Computational Medicine and Neuropsychiatry
Department of Otolaryngology-Head & Neck Surgery
Aix Marseille Univ
Section of Otolaryngology
Maxillofacial Surgery Unit
Division of Phoniatrics and Audiology
Otolaryngology Unit
Department of Otolaryngology-Head & Neck Surgery
Department of Otorhinolaryngology-Head & Neck Surgery
Department of Organi di Senso
Department of Otorhinolaryngology-Head & Neck Surgery
Department of Translational Neuroscience
University Medical Center Corporate Fund
Department of Human Anatomy and Experimental Oncology
Department of Otolaryngology-Head & Neck Surgery
Department of Otorhinolaryngology-Head & Neck Surgery
Department of ENT
Faculty of Health
Department of Medicine and Surgery

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