Poly(2-ethyl-2-oxazoline) grafted gellan gum for potential application in transmucosal drug delivery
Lavikainen J. Dauletbekova M. Toleutay G. Kaliva M. Chatzinikolaidou M. Kudaibergenov S.E. Tenkovtsev A. Khutoryanskiy V.V. Vamvakaki M. Aseyev V.
July 2021John Wiley and Sons Ltd
Polymers for Advanced Technologies
2021#32Issue 72770 - 2780 pp.
Gellan gum (GG) has been used to prepare polymeric carriers with prolonged retention on the eye surface for topical ocular drug delivery. In this work, GG was chemically modified with short poly(2-ethyl-2-oxazoline) (PEtOx) chains that were expected to have minimal adhesion to mucosal tissues (mucoadhesion). The choice of synthetic procedure, solvents, and reagents has been dictated by biocompatibility of the materials and possible application in drug delivery. The grafts were synthesized via cationic ring-opening polymerization and their living chains were attached onto deprotonated gellan backbone. The derivatives with three degrees of grafting were prepared by varying the in-feed mass ratio of PEtOx grafts over GG. NMR and FT-IR spectroscopies, thermogravimetric analysis, and SEC evidenced that the grafting had actually taken place. However, a greater diffusion coefficient determined for the copolymer, using diffusion-ordered spectroscopy (NMR), in relation to the diffusion of the unmodified GG, suggested either partial degradation of the backbone or a more compact structure of the copolymer. GG and its graft copolymers (GG-g-PEtOx) were found to be highly biocompatible with cells cultured under their induction at concentration of 1, 0.1 and 0.01 mg/mL demonstrated a physiological morphology, as well as an increase in viability and proliferation.
gellan gum , graft copolymer , mucoadhesion , mucus penetration , poly(2-ethyl-2-oxazoline)
Text of the article Перейти на текст статьи
Department of Chemistry, University of Helsinki, Helsinki, Finland
Institute of Polymer Materials and Technology, Almaty, Kazakhstan
Department of Materials Science and Technology, University of Crete, Crete, Greece
Institute of Electronic Structure and Laser, Foundation for Research and Technology—Hellas, Crete, Greece
Institute of Macromolecular Compounds of the Russian Academy of Sciences, Saint Petersburg, Russian Federation
Reading School of Pharmacy, University of Reading, Reading, United Kingdom
Department of Chemistry
Institute of Polymer Materials and Technology
Department of Materials Science and Technology
Institute of Electronic Structure and Laser
Institute of Macromolecular Compounds of the Russian Academy of Sciences
Reading School of Pharmacy
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026