Chitosan-coated iron(III) oxide nanoparticles and tungsten disulfide quantum dots-immobilized Fiber-based WaveFlex Biosensor for Staphylococcus Aureus bacterial detection in real food samples
Lang X. Singh R. Zeng Q. Li J. Tosi D. Nedoma J. Marques C. Zhang B. Kumar S.
December 2024Elsevier B.V.
Sensors and Actuators Reports
2024#8
The research proposes and investigates an extraordinarily sensitive, label-free WaveFlex biosensor utilizing optical fiber technology for the detection of Staphylococcus aureus (S. aureus), a common foodborne bacterium. The WaveFlex biosensor (plasmon Wave based Flexible optical fiber Biosensor) is based on a novel flexible tapered single-mode fiber structure, utilizing gold nanoparticles (AuNPs) to trigger the phenomenon of localized surface plasmon resonance (LSPR). Additionally, the sensitivity is further enhanced using chitosan-coated iron(III) oxide nanoparticles (Fe3O4–CS NPs) and tungsten disulfide quantum dots (WS2-QDs). The optical fiber surface is functionalized with antibodies to achieve specific detection of S. aureus. For S. aureus concentrations at 1 × 108 CFU/mL (colony-forming units per milliliter), the sensors maximum sensitivity of 2.74 nm/lg (CFU/mL), and a detection limit (LOD) of 6.67 CFU/mL. This ultra-sensitive biosensor holds great potential for widespread applications in various fields, including disease detection, medical diagnostics, and food safety inspection.
AuNPs , Fe3O4 –CS NPs , Optical fiber biosensors , S. aureus detection , WaveFlex biosensors
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Shandong Key Laboratory of Optical Communication Science and Technology, School of Physics Science and Information Technology, Liaocheng University, Liaocheng, 252059, China
Department of Biotechnology, Koneru Lakshmaiah Education Foundation, Andhra Pradesh, Vaddeswaram, 522302, India
Agricultural Science and Engineering School, Liaocheng University, Liaocheng, 252059, China
State Key Laboratory for Macromolecule Drugs and Large-scale Manufacturing, School of Pharmaceutical Sciences, Liaocheng University, Liaocheng, 252059, China
Department of Electrical and Computer Engineering, Nazarbayev University, Astana, 010000, Kazakhstan
Department of Telecommunications, VSB – Technical University of Ostrava, Ostrava, 70800, Czech Republic
CICECO – Aveiro Institute of Materials, Physics Department, University of Aveiro, Aveiro, 3810-193, Portugal
Department of Physics, VSB – Technical University of Ostrava, Ostrava, 70800, Czech Republic
Centre of Excellence for Nanotechnology, Department of Electronics and Communication Engineering, Koneru Lakshmaiah Education Foundation, Andhra Pradesh, Vaddeswaram, 522302, India
Shandong Key Laboratory of Optical Communication Science and Technology
Department of Biotechnology
Agricultural Science and Engineering School
State Key Laboratory for Macromolecule Drugs and Large-scale Manufacturing
Department of Electrical and Computer Engineering
Department of Telecommunications
CICECO – Aveiro Institute of Materials
Department of Physics
Centre of Excellence for Nanotechnology
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