Effect of Vitreoretinal Surgery Combined with Platelet-Rich Plasma on the Quality of Life of Patients with Macular Hole
Efecto de la cirugía vitreorretiniana combinada con plasma rico en plaquetas en la calidad de vida de pacientes con agujero macular
Kyrykbayev D.
1 January 2025AG Editor (Argentina)
Health Leadership and Quality of Life
2025#4
Introduction: this study evaluates the impact of pars plana vitrectomy (PPV) combined with internal limiting membrane (ILM) peeling and platelet-rich plasma (PRP) application on anatomical, functional, and quality-of-life (QoL) outcomes in patients with macular holes. Method: prospective cohort study. Tertiary eye care center, January 2021 to December 2023. A total of 155 patients underwent PPV with ILM peeling and PRP. Visual acuity (logMAR), macular hole closure, and QoL were assessed pre-and postoperatively. QoL evaluation used a localized adaptation of the NEI VFQ-25 questionnaire. Anatomical outcomes were measured by Optical Coherence Tomography (OCT). Results: the mean age was 65,90 ± 8,84 years; 38 % were female. The closure rate was 94 %. Visual acuity improved significantly, with average logMAR improving from 0,7 to 0,3 (p < 0,001). QoL scores improved across all domains: visual functioning increased from 55,3 to 85,7, daily activities from 48,2 to 80,4, and psychological well-being from 50,1 to 82,9. Patients reported greater independence and improved ability in activities like reading, recognizing faces, and participating in sports. Conclusion: PPV with ILM peeling and PRP is highly effective for macular holes, yielding strong anatomical and functional outcomes alongside significant QoL enhancements.
Internal Limiting Membrane Peel , Macular Hole , Pars Plana Vitrectomy , Platelet-Rich Plasma, Quality of Life, Ophthalmic Surgery
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Kazakh Scientific Research Institute of Eye Diseases, Almaty, Kazakhstan
Kazakh Scientific Research Institute of Eye Diseases
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