The Role of Mitochondrial miRNAs in the Development of Radon-Induced Lung Cancer
Kussainova A. Bulgakova O. Aripova A. Khalid Z. Bersimbaev R. Izzotti A.
February 2022MDPI
Biomedicines
2022#10Issue 2
MicroRNAs are short, non-coding RNA molecules regulating gene expression by inhibiting the translation of messenger RNA (mRNA) or leading to degradation. The miRNAs are encoded in the nuclear genome and exported to the cytosol. However, miRNAs have been found in mitochondria and are probably derived from mitochondrial DNA. These miRNAs are able to directly regulate mitochondrial genes and mitochondrial activity. Mitochondrial dysfunction is the cause of many diseases, including cancer. In this review, we consider the role of mitochondrial miRNAs in the pathogenesis of lung cancer with particular reference to radon exposure.
Lung cancer , MicroRNA , Mitochondrial microRNA , Radon
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Department of Health Sciences, University of Genova, Via Pastore 1, Genoa, 16132, Italy
Department of General Biology and Genomics, Institute of Cell Biology and Biotechnology, L.N. Gumilyov Eurasian National University, Nur-Sultan, Akmola, 010008, Kazakhstan
Department of Experimental Medicine, University of Genoa, Genoa, I-16132, Italy
IRCCS Ospedale Policlinico San Martino, Genoa, 16132, Italy
Department of Health Sciences
Department of General Biology and Genomics
Department of Experimental Medicine
IRCCS Ospedale Policlinico San Martino
10 лет помогаем публиковать статьи Международный издатель
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