Gene polymorphisms and serum levels of BDNF and CRH in vitiligo patients
Kussainova A. Kassym L. Bekenova N. Akhmetova A. Glushkova N. Kussainov A. Urazalina Z. Yurkovskaya O. Smail Y. Pak L. Semenova Y.
July 2022Public Library of Science
PLoS ONE
2022#17Issue 7 July
Background Vitiligo is one of the most common hypomelanoses, in which the destruction of functioning melanocytes causes depigmentation of the skin, hair and mucous membranes. The genes encrypting brain-derived neurotrophic factor (BDNF) and corticotropin releasing hormone (CRH) might be the conceivable contributors to the development of vitiligo. This study was aimed at investigation of the serum levels of BDNF and CRH as well as their selected single nucleotide polymorphisms (SNPs) in vitiligo patients in comparison with the healthy controls. Methods The cross-sectional study was carried out between October 2020 and June 2021 in 93 vitiligo patients (age range from 23 to 48 years) and 132 healthy controls (age range from 24 to 52 years). The psychological status of study participants was evaluated using the Generalized Anxiety Disorder-7 (GAD-7) scale. Serum levels of BDNF and CRH were measured with the help of a commercially available sandwich enzyme-linked immunosorbent assay (ELISA) kit. Genotyping for the rs11030094 polymorphism of the BDNF gene and for the rs242924 polymorphism of the corticotropin releasing hormone receptor 1 (CRH-R1) gene was performed by a real-time polymerase chain reaction (PCR). Results There was a significant relationship between the CRH-R1 rs242924 and BDNF rs11030094 polymorphisms and vitiligo. Moreover, serum levels of neurotransmitters differed significantly between vitiligo and control groups and were associated with the CRH-R1 rs242924 and BDNF rs11030094 SNPs. Conclusions Our findings demonstrated the association between CRH-R1 rs242924 and BDNF rs11030094 polymorphisms and vitiligo. Further studies need to be carried out in vitiligo patients to confirm the results observed. Copyright:
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Department of Dermatovenerology and Cosmetology, NJSC Semey Medical University, Semey, Kazakhstan
School of Medicine, Nazarbayev University, Nur-Sultan, Kazakhstan
Department of Epidemiology, Biostatistics & Evidence Based Medicine, Al-Farabi Kazakh National University, Almaty, Kazakhstan
Department of Psychiatry and Narcology, NJSC Astana Medical University, Nur-Sultan, Kazakhstan
Department of Emergency Medicine, NJSC Semey Medical University, Semey, Kazakhstan
Department of Personalized Medicine, NJSC Semey Medical University, Semey, Kazakhstan
Department of Infectious Diseases and Immunology, NJSC Semey Medical University, Semey, Kazakhstan
Department of Clinical Oncology and Nuclear Medicine, NJSC Semey Medical University, Semey, Kazakhstan
Department of Neurology, Ophthalmology, Otorhinolaryngology, NJSC Semey Medical University, Semey, Kazakhstan
Department of Dermatovenerology and Cosmetology
School of Medicine
Department of Epidemiology
Department of Psychiatry and Narcology
Department of Emergency Medicine
Department of Personalized Medicine
Department of Infectious Diseases and Immunology
Department of Clinical Oncology and Nuclear Medicine
Department of Neurology
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