Biochemical markers for prediction of the first half pregnancy losses: a review
Kuspanova M. Gaiday A. Dzhardemaliyeva N. Tuganbayev M. Gorobeiko M. Dinets A. Bermagambetova S. Amirbekova Z. Oraltayeva G. Omertayeva D. Tussupkaliyev A.
2024Federacao Brasileira das Sociedades de Ginecologia e Obstetricia
Revista Brasileira de Ginecologia e Obstetricia
2024#46
Objective: 26% of all pregnancies end in miscarriage, and up to 10% of clinically diagnosed pregnancies, and recurrent pregnancy loss is 5% among couples of childbearing ages. Although there are several known causes of pregnancy loss in the first half, including recurrent pregnancy loss, including parental chromosomal abnormalities, uterine malformations, endocrinological disorders, and immunological abnormalities, about half of the cases of pregnancy loss in its first half remain unexplained. Methods: The review includes observational controlled studies (case-control or cohort, longitudinal studies, reviews, meta-analyses), which include the study of biochemical factors for predicting pregnancy losses in the first half, in singlet pregnancy. The Newcastle-Ottawa Scale (NOS) was used to assess the research quality. Results: Finally, 27 studies were included in the review, which has 134904 examined patients. The results of the review include estimates of β-human chorionic gonadotropin, progesterone, pregnancy-associated protein – A, angiogenic vascular factors, estradiol, α-fetoprotein, homocysteine and CA-125 as a predictors or markers of the first half pregnancy losses. Conclusion: It may be concluded that to date, research data indicate the unavailability of any reliable biochemical marker for predicting pregnancy losses in its first half and require either a combination of them or comparison with clinical evidence. A fairly new model shall be considered for the assessment of α-fetoprotein in vaginal blood, which may have great prospects in predicting spontaneous miscarriages.
Biochemical marker , Laboratory marker , Miscarriage , Missed abortion , Prediction , Pregnancy , Spontaneous abortion
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Department of obstetrics and gynecology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Department of obstetrics and gynecology, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
Department of gynecology, Atyrau Regional Perinatal Center, Atyrau, Kazakhstan
Department of Surgery, Institute of Biology and Medicine, Taras Shevchenko National University of Kyiv, Kyiv, Ukraine
Department of Obstetrics, Gynecology and Perinatology, Medical University of Karaganda, Kazakhstan
Department of medical expertise, Regional Perinatal Center, Semey, Kazakhstan
Department of obstetrics and gynecology
Department of obstetrics and gynecology
Department of gynecology
Department of Surgery
Department of Obstetrics
Department of medical expertise
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