The relationship between Toll-like receptor-4 genes and preeclampsia outcomes

Kurmanova A. Urazbayeva G. Salimbayeva D. Terlikbayeva A. Kypshakbayeva Z. Smailov M.
July 2024 Springer

Journal of Assisted Reproduction and Genetics
2024 #41 Issue 7 1917 - 1923 pp.

Purpose: The study aimed to analyse the relationship of the rs4986790 locus of the TLR4 gene with the overall risk of preeclampsia, including both its early and late forms. Methods: The study used standard genetic analysis methods such as DNA extraction, PCR amplification, and genotyping of the rs4986790 locus of the TLR4 gene to assess the association with the development of preeclampsia and peripartal stroke in 207 pregnant women from the southern regions of Kazakhstan from 2016 to 2022, of whom 103 had peripartal stroke on the background of preeclampsia (the main group) and 104 preeclampsia (comparative group). Results: The results of the study demonstrate that the AG and AG + GG genotypes at the rs4986790 locus of the TLR4 gene are significantly associated with an increased risk of developing an early form of preeclampsia. This opens up a new perspective in the identification of genetic markers that can serve as indicators of a tendency to develop preeclampsia in earlier periods of pregnancy. Conclusion: It was noted that the rs4986790 locus did not show a statistically significant association with the risk of late preeclampsia. An important aspect of the study revealed the relationship of genotypes with the development of peripartal stroke on the background of preeclampsia. This study offers practical insights for creating targeted genetic screening and personalised treatments for preeclampsia, aiming to improve patient outcomes. To fully understand the molecular mechanisms underlying the identified association, additional research is required to identify deeper molecular pathways and relationships, and to develop new strategies for the prevention and treatment of preeclampsia.

Gestational hypertension , Locus rs4986790 , Markers , Polymorphism , Preeclampsia , Stroke

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Department of Clinical Subjects, Al-Farabi Kazakh National University, Almaty, Kazakhstan
The Scientific Center for Obstetrics, Gynecology and Perinatology, Almaty, Kazakhstan
Department of Strategic Development and Science, The Scientific Center for Obstetrics, Gynecology and Perinatology, Almaty, Kazakhstan
Faculty of Postgraduate Education, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan

Department of Clinical Subjects
The Scientific Center for Obstetrics
Department of Strategic Development and Science
Faculty of Postgraduate Education

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