Eryptosis in Liver Diseases: Contribution to Anemia and Hypercoagulation
Kurmangaliyeva S. Baktikulova K. Tkachenko A. Seitkhanova B. Tryfonyuk L. Rakhimzhanova F. Yussupov R. Kurmangaliyev K.
September 2025Multidisciplinary Digital Publishing Institute (MDPI)
Medical sciences
2025#13Issue 3
Eryptosis is a type of regulated cell death of mature erythrocytes characterized by excessive Ca2+ accumulation followed by phosphatidylserine externalization. Eryptosis facilitates erythrophagocytosis resulting in eradication of damaged erythrocytes, which maintains the population of healthy erythrocytes in blood. Over recent years, a wide array of diseases has been reported to be linked to accelerated eryptosis, which leads to anemia. A growing number of studies furnish evidence that eryptosis is implicated in the pathogenesis of liver diseases. Herein, we summarize the current knowledge of eryptosis signaling, its physiological role, and the impact of eryptosis on anemia and hypercoagulation. In this article, upon systemically analyzing the PubMed-indexed publications, we also provide a comprehensive overview of the role of eryptosis in the spectrum of hepatic diseases, its contribution to the development of complications in liver pathology, metabolites (bilirubin, bile acids, etc.) that might trigger eryptosis in liver diseases, and eryptosis-inducing liver disease medications. Eryptosis in liver diseases contributes to anemia, hypercoagulation, and endothelial damage (via ferroptosis of endothelial cells). Treatment-associated anemia in liver diseases might be at least partly attributed to drug-induced eryptosis. Ultimately, we analyze the concept of inhibiting eryptosis pharmaceutically to prevent eryptosis-associated anemia and thrombosis in liver diseases.
bile acids , bilirubin , chronic liver disease , eryptosis , non-alcoholic fatty liver disease , regulated cell death
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Department of Microbiology, Virology, and Immunology, NJSC “West Kazakhstan Marat Ospanov Medical University”, 68 Maresyev st, Aktobe, 030000, Kazakhstan
BIOCEV, First Faculty of Medicine, Charles University, Průmyslová 595, Vestec, 25250, Czech Republic
Department of Microbiology, Virology, and Immunology, NJSC “South Kazakhstan Medical Academy”, Al-Farabi sq, Shymkent, 160019, Kazakhstan
Institute of Health, National University of Water and Environmental Engineering, 11 Soborna st, Rivne, 33028, Ukraine
Rivne Regional Clinical Hospital, 78g Kyivska st, Rivne, 33007, Ukraine
Department of Microbiology, NJSC “Semey Medical University”, 103 Abay st, Semey, 071400, Kazakhstan
Department of Microbiology, Virology, Republic NJSC “Kazakh National Medical University Named after S.D. Asfendiyarov”, 94 Tole Bi, Almaty, 005000, Kazakhstan
Department of Microbiology
BIOCEV
Department of Microbiology
Institute of Health
Rivne Regional Clinical Hospital
Department of Microbiology
Department of Microbiology
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