Thermo-Visco-Elastometry of RF-Wave-Heated and Ablated Flesh Tissues Containing Au Nanoparticles
Kurbanova B. Ashikbayeva Z. Amantayeva A. Sametova A. Blanc W. Gaipov A. Tosi D. Utegulov Z.
January 2023MDPI
Biosensors
2023#13Issue 1
We report non-contact laser-based Brillouin light-scattering (BLS) spectroscopy measurements of the viscoelastic properties of hyperthermally radiofrequency (RF)-heated and ablated bovine liver and chicken flesh tissues with embedded gold nanoparticles (AuNPs). The spatial lateral profile of the local surface temperature in the flesh samples during their hyperthermia was measured through optical backscattering reflectometry (OBR) using Mg–silica-NP-doped sensing fibers distributed with an RF applicator and correlated with viscoelastic variations in heat-affected and ablated tissues. Substantial changes in the tissue stiffness after heating and ablation were directly related to their heat-induced structural modifications. The main proteins responsible for muscle elasticity were denatured and irreversibly aggregated during the RF ablation. At T > 100 °C, the proteins constituting the flesh further shrank and became disorganized, leading to substantial plastic deformation of biotissues. Their uniform destruction with larger thermal lesions and a more viscoelastic network was attained via AuNP-mediated RF hyperthermal ablation. The results demonstrated here pave the way for simultaneous real-time hybrid optical sensing of viscoelasticity and local temperature in biotissues during their denaturation and gelation during hyperthermia for future applications that involve mechanical- and thermal-property-controlled theranostics.
ablation , Brillouin spectroscopy , fiber-optic , flesh , gold nanoparticles , heating , hyperthermia , metal nanoparticle , protein denaturation , radiofrequency , sensors , temperature , theranostics , thermometry , viscoelastic
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Department of Physics, School of Sciences and Humanities, Nazarbayev University, Astana, 010000, Kazakhstan
School of Engineering and Digital Sciences, Nazarbayev University, Astana, 010000, Kazakhstan
Université Côte d’Azur, INPHYNI, CNRS UMR7010, Avenue Joseph Vallot, Nice, 06108, France
Department of Medicine, Nazarbayev University School of Medicine, Astana, 010000, Kazakhstan
National Laboratory Astana, Laboratory of Biosensors and Bioinstruments, Astana, 010000, Kazakhstan
Department of Physics
School of Engineering and Digital Sciences
Université Côte d’Azur
Department of Medicine
National Laboratory Astana
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