In-situ, real-time monitoring of thermo-mechanical properties of biological tissues undergoing laser heating and ablation
Kurbanova B. Alisherov S. Ashikbayeva Z. Katrenova Z. Sametova A. Gaipov A. Molardi C. Blanc W. Tosi D. Utegulov Z.
1 November 2024Optica Publishing Group (formerly OSA)
Biomedical Optics Express
2024#15Issue 116198 - 6210 pp.
In this work, Brillouin light-scattering spectroscopy and optical backscattering reflectometry (OBR) using Mg–silica-NP-doped distributed sensing fibers were employed for monitoring local GHz visco-elastic properties and surface temperature, respectively, during laser driven heating and ablation of chicken tissues. The spatial temperature distribution measured by OBR at various infrared laser heating powers and times was used to validate spatio-temporal local temperature variations modeled by the finite element method via solving Pennes’ bioheat conduction equation. The reduction of viscosity and stiffness in chicken skin during its laser heating was attributed to water loss, protein denaturation and change in lipid phase behavior. These findings open avenues for the simultaneous real-time hybrid optical sensing of both viscoelasticity and local temperature in biological tissues undergoing denaturation and gelation during thermal ablation in clinical settings.
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Department of Physics, School of Sciences and Humanities, Nazarbayev University, Astana, 010000, Kazakhstan
Department of Electrical and Computer Engineering, School of Engineering and Digital Sciences, Nazarbayev University, Astana, 010000, Kazakhstan
Laboratory of Biosensors and Bioinstruments, National Laboratory Astana, Astana, 010000, Kazakhstan
Department of Medicine, Nazarbayev University School of Medicine, Astana, 010000, Kazakhstan
Université Ĉote d’Azur, INPHYNI, CNRS UMR7010, 17 rue Julien Lauprêtre, Nice, 06200, France
Department of Physics
Department of Electrical and Computer Engineering
Laboratory of Biosensors and Bioinstruments
Department of Medicine
Université Ĉote d’Azur
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