Stem cell therapy for chronic diffuse liver lesions: main symptoms and causes
Kurakbayev Y. Saparbayev S. Turdalieva B. Baimuratova M. Sarsembayev B.
2025Termedia Publishing House Ltd.
Przeglad Gastroenterologiczny
2025#20Issue 3318 - 324 pp.
Introduction: Chronic liver damage is one of the most important and complex problems in modern gastroenterology. The relevance of studying chronic hepatitis of various aetiologies is associated with its high socio-economic and medical significance due to the steady progressive course, with the development of fibrosis, and then cirrhosis of the liver. Aim: The purpose of this study was to search for and analyse new biotechnological methods for the treatment of diffuse liver diseases to improve patient survival, since the main contingent of patients is typically the able-bodied, socially active part of the population. Material and methods: To achieve this goal, general theoretical methods of scientific knowledge were used, such as analysis, generalization, questioning, and systematization. Results: The article presents a meta-analysis of the results of studies conducted in the field of cellular technologies by leading scientists in the field of the treatment of liver diseases. The issues of transdifferentiation, the mechanisms of action of stem cells in hepatology, as well as the possible risks of this therapy (pro-oncogenic effect, increased fibrosis), are covered. Conclusions: Cell therapy in embryonic, mononuclear, and mesenchymal stromal cells is the most advanced area of modern biotechnology and medicine. Its therapeutic application in chronic liver diseases is base on the possibility of regulating disturbed intercellular interactions in the liver, influencing the mechanisms of cell death (necrosis, apoptosis) and fibrogenesis, which makes this method the most relevant and promising in hepatology. Copyright
anamnesis , cirrhosis , hepatitis , hepatocytes , mesenchymal cells , patient tests
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Kazakhstan Medical University “KSPH”, Almaty, Kazakhstan
West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
Kazakhstan Medical University “KSPH”
West Kazakhstan Marat Ospanov Medical University
Asfendiyarov Kazakh National Medical University
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Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026