Stimuli-responsive Hydrogels for Targeted Antibiotic Delivery in Bone Tissue Engineering
Kumar J. M T. Musayev A. Danyshbayeva A. Begimbekova L. Kumar H. Gulnar T. Kumar P. Shamim S.
October 2025Springer Science and Business Media Deutschland GmbH
AAPS PharmSciTech
2025#26Issue 7
Bone tissue engineering (BTE) faces critical challenges in managing infections such as osteomyelitis, which complicate healing and compromise implant success. Conventional antibiotic therapies often fail to achieve effective localized drug concentrations without systemic toxicity. Stimuli-responsive hydrogels have emerged as a transformative solution, offering spatiotemporally controlled, on-demand antibiotic release triggered by environmental cues such as pH, temperature, enzymatic activity, and redox conditions. This review comprehensively analyzes hydrogel classification, design strategies, and their integration within BTE scaffolds. It highlights the synergistic benefits of smart hydrogels in supporting osteogenic differentiation, enhancing vascularization, and combating infection. Key antibiotic delivery mechanisms—from enzyme-sensitive nanocomposites to dual-stimuli systems—are critically examined alongside their pharmacokinetic advantages and limitations. The article also discusses current translational barriers, including mechanical stability, biocompatibility, and regulatory hurdles, while presenting future directions such as biosensing-enabled, 3D-bioprinted, and AI-assisted platforms. Overall, stimuli-responsive hydrogels represent a promising paradigm in precision antibiotic delivery and regenerative bone therapy.
bioactive scaffolds , bone tissue engineering , environment-sensitive drug release , localized antibiotic delivery , smart biomaterials , stimuli-responsive hydrogels
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Department of Pharmaceutical Chemistry, SRM Modinagar College of Pharmacy, SRM Institute of Science and Technology, Uttar Pradesh, Delhi-NCR Campus, Modinagar, Ghaziabad, 201204, India
Department of Pathological Physiology, Kazakh National Medical University, Almaty, 050000, Kazakhstan
International Kazakh-Turkish University (Ahmet Yassawi University), Turkistan, 161200, Kazakhstan
School of Pharmaceutical Sciences, Om Sterling Global University, Haryana, Hisar, 125001, India
Department of Pharmaceutical Sciences and Technology, Maharaja Ranjit Singh Punjab Technical University, Punjab, Bathinda, 151001, India
Department of Pharmacy, IIMT College of Medical Sciences, IIMT University, Ganga Nagar, Uttar Pradesh, Meerut, 250001, India
Department of Pharmaceutical Chemistry
Department of Pathological Physiology
International Kazakh-Turkish University (Ahmet Yassawi University)
School of Pharmaceutical Sciences
Department of Pharmaceutical Sciences and Technology
Department of Pharmacy
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Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026