Relationship between vitamin d status and cortisol in girls with primary dysmenorrhea
Kulzhanova D. Amanzholkyzy A. Donayeva A. Sarkulova Z. Sarkulov M. Ainur T. Sagidanova Y. Balmaganbetova F. Saparbayev S. Mannapova A. Zagorulya N. Kubekova S. Baubekova A.
17 May 2025Ibn Sina Trust
Bangladesh Journal of Medical Science
2025#24Issue 2496 - 504 pp.
Background & Aims Many adolescent girls and young women experience painful periods, medically known as primary dysmenorrhea (PD). Vitamin D deficiency and high cortisol levels seem to be connected and may even worsen the symptoms of PD. The aim of this research was to determine possible relationship between vitamin D and salivary cortisol levels in adolescent girls with PD. Methodology A total of 191 adolescent girls with PD aged 13-16 years were examined. All participants were randomly divided into two groups: the main group (n =96), which took vitamin D 4000 IU per day for three months and the control group (n =95), which took placebo. Further laboratory tests were carried out to determine the level of 25(OH) vitamin D in the blood serum and 4 samples of saliva to evaluate cortisol levels during the day before and after the intervention. Results & Conclusion After the intervention in the main group, an average negative relationship was revealed between the content of 25(OH) vitamin D in the blood with morning (r=-0.4, p=0.001) and daytime (r=-0.25, p=0.041) levels of cortisol in the saliva of adolescent girls with PD, while no significant relationships were identified in the control group. We found that higher vitamin D levels were linked to lower cortisol levels in their saliva, especially in the mornings. This suggests a potential benefit of vitamin D in reducing stress hormones in these girls.
adolescent girls , cortisol , Primary dysmenorrhea , vitamin D
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Department of normal physiology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Department of anesthesiology and reanimatology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Departments of urology and andrology, including children’s, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Department of Obstetrics and Gynecology, Astana Medical University, Astana, Kazakhstan
Department of normal physiology
Department of anesthesiology and reanimatology
Departments of urology and andrology
Department of Obstetrics and Gynecology
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