A new metabolite from Cunninghamella blakesleeana-mediated biotransformation of an oral contraceptive drug, levonorgestrel
Kudaibergenova B.M. Wahab A.-T. Siddiqui M. Abilov Z.A. Choudhary M.I.
2021Taylor and Francis Ltd.
Natural Product Research
2021#35Issue 122095 - 2098 pp.
Cunninghamella blakesleeana-mediated biotransformation of an oral contraceptive drug, levonorgestrel (1), yielded a new metabolite, 13β-ethyl-17α-ethynyl-10,17β-dihydroxy-4,6-dien-3-one (2), and two known metabolites 3 (13β-ethyl-17α-ethynyl-10β,17β-dihydroxy-4-en-3-one), and 4 (13β-ethyl-17α-ethynyl-6β,17β-dihydroxy-4-en-3-one) at an ambient temperature using aqueous media. Hydroxylation and dehydrogenation of compound 1 was observed during the bio-catalytic transformation. The structure of a new metabolite 2 was determined by 1H, 13C, and 2DNMR and HR-EIMS spectroscopic techniques.
biotransformation , Contraceptive drug , Cunninghamella blakesleeana , levonorgestrel
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Department of Chemistry, Al-Farabi Kazakh National University, Almaty, Kazakhstan
Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan
H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan
Department of Chemistry
Dr. Panjwani Center for Molecular Medicine and Drug Research
H. E. J. Research Institute of Chemistry
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