A combination of bioflavonoid, oral thrombolytic and anticoagulant in the treatment of thrombophlebitis of varicose veins in outpatient surgical practice
Krivoshchekov E.P. Poseryaev A.V. Khoroshilov M.Yu. Romanov V.E. Rakhimov B.M. Kazantsev A.V. Kirgizbaev S.Zh.
2024Remedium Group Ltd
Ambulatornaya Khirurgiya
2024#21Issue 260 - 69 pp.
Introduction. Comparability of the outcomes of treatment of patients with thrombophlebitis of varicose veins using surgical intervention and medical therapy, a wide range of drugs have become the basis for conducting this study. Aim. To evaluate the effectiveness of the use of micronized purified flavonoid fraction in comparison with the isolated use of diosmin in patients with superficial varicothrombophlebitis in outpatient surgical practice. Materials and methods. From 2021 to 2022, a prospective study of the treatment results of 82 patients (from 42 to 68 years old, average age: 54.3 ± 12.34 years) with a diagnosis of superficial vein thrombophlebitis was conducted. To relieve inflammation as soon as possible and accelerate recanalization, a direct oral thrombolytic was prescribed. The patients were divided into two groups. The main group (44 patients) took a drug consisting of diosmin 900 mg (90%) and flavonoids in terms of hesperidin 100 mg (10%). In the comparison group (38 people), unmicronized diosmin was taken at a dosage of 600 mg. Results and discussion. Thrombophlebitis of superficial veins was more often localized in the basin of the great saphenous vein (47 patients (57.3%)). On the 30th day after the start of treatment, there was no progression of the thrombotic process. In the main and control groups, the symptoms of thrombophlebitis (a feeling of tightness under the skin and local soreness in the area of varicose veins) were eliminated in 34 (77.3%) of the main group and 22 (57.9%) patients of the comparison group. There was a decrease in the signs of chronic venous insufficiency from 73.7 to 36.4%, as well as a statistically large proportion of patients with complete or partial recanali-zation (70.5 vs 44.5% in the control group). Conclusion. The results of the study show that the micronized purified flavonoid fraction has advantages over non-micronized diosmin in reducing the severity of symptoms, significantly reducing the signs of chronic venous insufficiency and improving quality.
anticoagulant , micronized purified flavonoid fraction , thrombolytic , thrombophlebitis , thrombosis , ventricular thromboembolism
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Department of Surgery with a Course in Cardiovascular Surgery, Institute of Professional Education, Samara State Medical University, 89, Chapaevskaya St, Samara, 443099, Russian Federation
Ulyanovsk Regional Clinical Hospital, 7, Third International St., Ulyanovsk, 432017, Russian Federation
Regional Clinical Hospital named after V.D. Seredavin, 159, Tashkentskaya St., Samara, 443095, Russian Federation
Territorial Compulsory Medical Insurance Fund of the Samara Region, 60, Vladimirskaya St., Samara, 443082, Russian Federation
Togliatti City Clinical Hospital No. 5, 25, Boulevard Zdorovya, Togliatti, 445039, Russian Federation
Cardiac Surgery Department No. 14, Samara Regional Clinical Cardiology Dispensary named V.P. Polyakov, 43, Aerodromnaya St., Samara, 443070, Russian Federation
Department of Cardiovascular Surgery, School of General Medicine-2, Asfendiyarov Kazakh National Medical University, 94, Tole Bi St., Almaty, 050012, Kazakhstan
Department of Surgery with a Course in Cardiovascular Surgery
Ulyanovsk Regional Clinical Hospital
Regional Clinical Hospital named after V.D. Seredavin
Territorial Compulsory Medical Insurance Fund of the Samara Region
Togliatti City Clinical Hospital No. 5
Cardiac Surgery Department No. 14
Department of Cardiovascular Surgery
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