Botulinum therapy of spastic forms of cerebral palsy in various locomotor patterns

Krasavina D.A. Chemeris A.V. Orlova O.R. Ivanov Y.I.
2021 Media Sphera Publishing Group

Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova
2021 #121 Issue 6 119 - 123 pp.

Spasticity in patients with cerebral palsy (CP) is the main impediment to normal locomotion. The function of the Central Pattern Generator (CPG), i.e. a group of neural chains in the spinal cord, stands at the core of any rhythmical movement. CPG can generate locomotion patterns without supraspinal control, which can have both positive and negative impact on the ability to move. Performing the motor tasks such as walking, running and swimming, creates the consistent rhythmical movement of legs and arms through interaction between CPGs of upper and lower extremities. This interaction can cause the activation of pathological movement patterns in lower extremities in response to upper limb spasticity. Thus, neural chains in the spinal cord become the generator of pathologically increased excitation which has developed as a result of a focal lesion in the CNS. All the statements de-scribed above show the importance of introducing the upper limb injections of bFotulinum toxin A in the protocol in order to develop normal locomotion. The PUL study approved the optimal level of efficacy and favourable safety profile of botulinum toxin A in children with CP and upper limb muscle spasticity.

Abobotulotoxin , Central pattern generator , Cerebral palsy , Locomotion , Spasticity

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Saint-Petersburg Institute for Advanced Training of Medical Experts, St. Petersburg, Russian Federation
Kazakhstan Medical University of Continuing Education, Almaty, Kazakhstan
Sechenov First Moscow State Medical University, Moscow, Russian Federation

Saint-Petersburg Institute for Advanced Training of Medical Experts
Kazakhstan Medical University of Continuing Education
Sechenov First Moscow State Medical University

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