Osteoporosis: Relevance of Biomolecules for Diagnosis and Treatment
Kozopas V. Humeniuk V. Semenova Y. Peana M. Butnariu M. Lysiuk R. Bjørklund G.
2025Bentham Science Publishers
Current Medicinal Chemistry
2025#32Issue 367976 - 7991 pp.
Osteoporosis, a metabolic disorder distinguished by decreased bone density and degradation of bone tissue microarchitecture, is a silent disease that evolves without any clinical symptoms or signs. An individual may not be aware of osteoporosis until a fracture occurs. The lifetime risk of osteoporosis is estimated to be between 10 and 20%. The disease can have intrinsic causes, such as genetic predisposition, aging, and lack of sex hormones. However, it can also occur secondary to calcium and vitamin D deficiencies due to the influence of various factors. With a global increase in osteoporotic fractures, there is a need for macro-level and micro-level interventions to prevent and treat osteoporosis and its complications. This review highlights the crucial role of various biomolecules in diagnosing and managing osteoporosis and emphasizes the importance of further research in the field. Bentham Science Publishers
biomolecules , bone mineral density , bone tissue , Osteoporosis , risk factors , sex hormones
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Danylo Halytsky Lviv National Medical University, Lviv, Ukraine
CONEM Ukraine Life Science Research Group, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine
School of Medicine, Nazarbayev University, Astana, Kazakhstan
Department of Chemical, Physical, Mathematical and Natural Sciences, University of Sassari, Sassari, Italy
Agricultural Sciences and Veterinary Medicine, Banat’s University, King Michael I of Romania” from Timisoara, Timis, Romania
CONEM Romania Biotechnology and Environmental Sciences Group, University of Life Sciences “King Mihai I” from Timisoara, Timis, Romania
Council for Nutritional and Environmental Medicine (CONEM), Mo i Rana, Norway
Danylo Halytsky Lviv National Medical University
CONEM Ukraine Life Science Research Group
School of Medicine
Department of Chemical
Agricultural Sciences and Veterinary Medicine
CONEM Romania Biotechnology and Environmental Sciences Group
Council for Nutritional and Environmental Medicine (CONEM)
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