Organosilica nanoparticles functionalised with p-anisaldehyde and p-chlorobenzaldehyde Schiff bases: Synthesis, physicochemical properties, toxicological and antimicrobial evaluation
Kozhantayeva Z.E. Walton G. Irmukhametova G.S. Khutoryanskiy V.V.
July 2026Elsevier Ltd
Biomaterials Advances
2026#184
In this study, bifunctional organosilica nanoparticles bearing thiol and amine functionalities were synthesized, PEGylated, and subsequently functionalised with aromatic aldehydes via Schiff base formation. The nanoparticles were prepared by an Ouzo effect–based nanoprecipitation method using 3-mercaptopropyltrimethoxysilane and 3-aminopropyltrimethoxysilane as precursors. Comprehensive physicochemical characterisation was performed using dynamic light scattering, nanoparticle tracking analysis, transmission electron microscopy, ζ-potential measurements, Ellmans and 4-nitrobenzaldehyde assays, FTIR spectroscopy, and X-ray diffraction. PEGylation markedly improved colloidal stability, resulting in aggregation-free dispersions across a broad pH range. In vivo toxicological assessment using Schmidtea mediterranea planaria demonstrated good biocompatibility of all nanoparticle formulations, with no evidence of epithelial barrier disruption. Antimicrobial activity was evaluated in vitro against Staphylococcus aureus . Nanoparticles functionalised with aromatic aldehydes exhibited pronounced antibacterial activity, whereas PEGylated nanoparticles showed only weak effects and non-functionalised nanoparticles were inactive.
Organosilica nanoparticles , Polyethylene glycol , Schiff bases , Surface modification, antimicrobial activity
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Department of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Almaty, 050040, Kazakhstan
Department of Food and Nutritional Sciences, University of Reading, Whiteknights, Reading, RG6 6DX, United Kingdom
Reading School of Pharmacy, University of Reading, Whiteknights, Reading, RG6 6DX, United Kingdom
Physicochemical, Ex Vivo and Invertebrate Tests and Analysis Centre (PEVITAC), University of Reading, Reading, RG6 6AD, United Kingdom
Department of Chemistry and Chemical Technology
Department of Food and Nutritional Sciences
Reading School of Pharmacy
Physicochemical
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